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Literature summary extracted from
- Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase (2010), Bioorg. Med. Chem. Lett., 20, 6882-6885.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.3.1 | - |
Candida albicans |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.70 | (2-methyl-1H-indol-3-yl)(oxo)acetic acid | - |
Staphylococcus aureus |  |
| 3.4.22.70 | (6-hydroxy-1H-indol-3-yl)(oxo)acetic acid | - |
Staphylococcus aureus | |
| 3.4.22.70 | (6-methoxy-1H-indol-3-yl)(oxo)acetic acid | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-pentyl-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ol | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1-phenyl-4,9-dihydro-3H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 1H-indol-3-yl(oxo)acetic acid | - |
Staphylococcus aureus | |
| 3.4.22.70 | 2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid | - |
Staphylococcus aureus | |
| 3.4.22.70 | 2-(1H-indol-3-yl)-2-oxo-N-phenylacetamide | - |
Staphylococcus aureus | |
| 3.4.22.70 | 2-(2-methyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide | - |
Staphylococcus aureus | |
| 3.4.22.70 | 2-(6-hydroxy-1H-indol-3-yl)-2-oxo-N-phenylacetamide | - |
Staphylococcus aureus | |
| 3.4.22.70 | 2-(6-methoxy-1H-indol-3-yl)-2-oxo-N-phenylacetamide | - |
Staphylococcus aureus | |
| 3.4.22.70 | 2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone | - |
Staphylococcus aureus | |
| 3.4.22.70 | 3-(2-aminoethyl)-1H-indol-5-ol | - |
Staphylococcus aureus | |
| 3.4.22.70 | 5-hydroxy-1H-indole-3-carbaldehyde | - |
Staphylococcus aureus | |
| 3.4.22.70 | 6-hydroxy-2,3,4,9-tetrahydro-1H-beta-carbolin-1-one | - |
Staphylococcus aureus | |
| 3.4.22.70 | 6-hydroxydihydro-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 7-hydroxy-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid | - |
Staphylococcus aureus | |
| 3.4.22.70 | 7-methoxy-1-pentyl-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 7-methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 7-methoxy-1-phenyl-4,9-dihydro-3H-beta-carboline | - |
Staphylococcus aureus | |
| 3.4.22.70 | 7-methoxy-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid | - |
Staphylococcus aureus | |
| 3.4.22.70 | methyl 5-hydroxy-1H-indole-3-carboxylate | - |
Staphylococcus aureus | |
| 3.4.22.70 | additional information | not inhibited by 3-nitropropionate | Staphylococcus aureus | |
| 3.4.22.70 | p-hydroxymercuribenzoic acid | - |
Staphylococcus aureus | |
| 4.1.3.1 | 1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione | - |
Candida albicans | |
| 4.1.3.1 | 1-(2-aminoethyl)-1H-indol-6-ol | - |
Candida albicans | |
| 4.1.3.1 | 1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline | - |
Candida albicans | |
| 4.1.3.1 | 1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline | - |
Candida albicans | |
| 4.1.3.1 | 1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline | - |
Candida albicans | |
| 4.1.3.1 | 2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone | - |
Candida albicans | |
| 4.1.3.1 | 3-nitropropionate | - |
Candida albicans | |
| 4.1.3.1 | 5-hydroxy-1H-indole-3-carbaldehyde | - |
Candida albicans | |
| 4.1.3.1 | 6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid | - |
Candida albicans | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.70 | Staphylococcus aureus | - |
- |
- |
| 4.1.3.1 | Candida albicans | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.3.1 | - |
Candida albicans |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.70 | SrtA | - |
Staphylococcus aureus |
| 4.1.3.1 | isocitrate lyase | - |
Candida albicans |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.70 | 0.0106 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ol | |
| 3.4.22.70 | 0.0115 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 7-methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline | |
| 3.4.22.70 | 0.025 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 7-methoxy-1-phenyl-4,9-dihydro-3H-beta-carboline | |
| 3.4.22.70 | 0.042 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | p-hydroxymercuribenzoic acid | |
| 3.4.22.70 | 0.061 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 2-(2-methyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide | |
| 3.4.22.70 | 0.067 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 6-hydroxydihydro-beta-carboline | |
| 3.4.22.70 | 0.069 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 1H-indol-3-yl(oxo)acetic acid | |
| 3.4.22.70 | 0.097 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 1-phenyl-4,9-dihydro-3H-beta-carboline | |
| 3.4.22.70 | 0.133 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | (2-methyl-1H-indol-3-yl)(oxo)acetic acid | |
| 3.4.22.70 | 0.174 | - |
pH and temperature not specified in the publication | Staphylococcus aureus | 2-(1H-indol-3-yl)-2-oxo-N-phenylacetamide | |
| 4.1.3.1 | 0.051 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 3-nitropropionate | |
| 4.1.3.1 | 0.075 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline | |
| 4.1.3.1 | 0.089 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione | |
| 4.1.3.1 | 0.137 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline | |
| 4.1.3.1 | 0.18 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline | |
| 4.1.3.1 | 0.247 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 5-hydroxy-1H-indole-3-carbaldehyde | |
| 4.1.3.1 | 0.301 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 1-(2-aminoethyl)-1H-indol-6-ol | |
| 4.1.3.1 | 0.318 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone | |
| 4.1.3.1 | 0.38 | - |
pH not specified in the publication, temperature not specified in the publication | Candida albicans | 6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid | |
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