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Literature summary extracted from

  • Nachon, F.; Carletti, E.; Wandhammer, M.; Nicolet, Y.; Schopfer, L.; Masson, P.; Lockridge, O.
    X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger (2011), Biochem. J., 434, 73-82.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.8 mutant GG117H is expressed in CHO cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.8 mutant enzyme G117H without additives and bound to MgF3-, sulfate, echothiophate, or VX, hanging drop vapor diffusion method Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.8 G117H the mutation leads to the creation of organophosphylate hydrolase activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens P06276
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 echothiophate + H2O substrate for mutant enzyme G117H Homo sapiens ?
-
 ?
3.1.1.8 ethyl ([2-[bis(propan-2-yl)amino]ethyl]-sulfanyl)(methyl)phosphinate + H2O substrate for mutant enzyme G117H Homo sapiens ?
-
 ?
3.1.1.8 sarin + H2O substrate for mutant enzyme G117H Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Homo sapiens
3.1.1.8 butyrylcholinesterase
-
 Homo sapiens