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Literature summary extracted from

  • Mirhashemi, S.; Moshtaghie, A.; Ani, M.; Aarabi, M.
    In vivo and in vitro studies of kinetic changes of serum, liver and brain high and low molecular weight alkaline phosphatase following aluminium exposure in rat (2010), Asian J. Biochem., 5, 1-11.
No PubMed abstract available

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.1 Al3+ inhibits high molecular weight and low molecular weight alkaline phosphatase non-competitively Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.1 brain
-
 Rattus norvegicus
-
3.1.3.1 liver
-
 Rattus norvegicus
-
3.1.3.1 serum
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
3.1.3.1 high molecular weight alkaline phosphatase
-
 Rattus norvegicus
3.1.3.1 low molecular weight alkaline phosphatase
-
 Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.3.1 additional information
-
 high molecular weight alkaline phosphatase is less heat and urea stable than low molecular weight alkaline phosphatase Rattus norvegicus
3.1.3.1 additional information
-
 low molecular weight alkaline phosphatase is more heat and urea stable than high molecular weight alkaline phosphatase Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.1.3.1 Rattus norvegicus in vivo studies show that injection of AlCl3 in male rats results in decreased expression of brain and liver alkaline phosphatase. Gel filtration experiments disclose a high level of high molecular weight alkaline phosphatase compared to control animals down
3.1.3.1 Rattus norvegicus in vivo studies show that injection of AlCl3 in male rats results in decreased expression of brain and liver alkaline phosphatase. Gel filtration studies show a significant reduction in low molecular weight alkaline phosphatase compared to control groups down
3.1.3.1 Rattus norvegicus in vivo studies show that injection of AlCl3 in male rats results in an increased expression of serum alkaline phosphatase up