Literature summary extracted from

Jung, W.S.; Yoo, Y.J.; Park, J.W.; Park, S.R.; Han, A.R.; Ban, Y.H.; Kim, E.J.; Kim, E.; Yoon, Y.J.
A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253 (2011), Appl. Microbiol. Biotechnol., 91, 1389-1397.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
6.4.1.3	introduced into Streptomyces hygroscopicus UV2-2 strain by conjugation from Escherichia coli ET12567/pUZ8002	Streptomyces hygroscopicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.4.1.3	Streptomyces hygroscopicus	-	-	-
6.4.1.3	Streptomyces hygroscopicus ATCC 29253	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.4.1.3	propionyl-CoA + CO2	-	Streptomyces hygroscopicus	(2S)-methylmalonyl-CoA	-	?
6.4.1.3	propionyl-CoA + CO2	-	Streptomyces hygroscopicus ATCC 29253	(2S)-methylmalonyl-CoA	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
6.4.1.3	PCC	-	Streptomyces hygroscopicus
6.4.1.3	Propionyl-CoA carboxylase	-	Streptomyces hygroscopicus

General Information

EC Number	General Information	Comment	Organism
6.4.1.3	physiological function	the PCC pathway is the dominant route for the supply of methylmalonyl-CoA for rapamycin production in Streptomyces hygroscopicus UV2-2 strain	Streptomyces hygroscopicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)