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Literature summary extracted from
- Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography (2011), Appl. Biochem. Biotechnol., 165, 336-346.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | edrophonium | - |
Ovis aries |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.7 | soluble | - |
Ovis aries | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 67040 | - |
4 * 67040, calculated from SDS-PAGE | Ovis aries |
| 3.1.1.7 | 201500 | - |
gel filtration | Ovis aries |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Ovis aries | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.7 | concanavalin A-Sepharose 4B column chromatography and edrophonium-Sepharose 6B column chromatography | Ovis aries |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | liver | - |
Ovis aries | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 21 | - |
after 842fold purification, pH and temperature not specified in the publication | Ovis aries |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylcholine + H2O | - |
Ovis aries | choline + acetate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | homotetramer | 4 * 67040, calculated from SDS-PAGE | Ovis aries |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | acetylcholine acetylhydrolase | - |
Ovis aries |
| 3.1.1.7 | AChE | - |
Ovis aries |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | physiological function | AChE is a pivotal enzyme in the cholinergic nervous system. Its primary function is to catalyze hydrolysis of released acetylcholine and thus maintain homeostasis of this neurotransmitter in the central and peripheral nervous systems | Ovis aries |
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Release 2023.1 (January 2023)
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