Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Davis, A.K.; Makar, R.S.; Stowell, C.P.; Kuter, D.J.; Dzik, W.H.
    ADAMTS13 binds to CD36: a potential mechanism for platelet and endothelial localization of ADAMTS13 (2009), Transfusion, 49, 206-213.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 cell surface
-
 Homo sapiens 9986
-
3.4.24.87 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 additional information Homo sapiens ADAMTS13 contains eight thrombospondin type 1 repeats and binds to CD36, a transmembrane protein present on endothelial cells and platelets. CD36 also binds to thrombospondin-2 via three thrombospondin type 1 repeats in a manner competitive to ADAMTS13, overview ?
-
 ?
3.4.24.87 von Willebrand factor + H2O Homo sapiens ADAMTS13 cleaves ultra-large von Willebrand factor multimers ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 blood platelet ADAMTS13 associates to the platelet surface via binding of membrane-integrated CD36 Homo sapiens
-
3.4.24.87 endothelial cell ADAMTS13 associates to the cell surface via binding of membrane-integrated CD36 Homo sapiens
-
3.4.24.87 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 additional information ADAMTS13 contains eight thrombospondin type 1 repeats and binds to CD36, a transmembrane protein present on endothelial cells and platelets. CD36 also binds to thrombospondin-2 via three thrombospondin type 1 repeats in a manner competitive to ADAMTS13, overview Homo sapiens ?
-
 ?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves ultra-large von Willebrand factor multimers Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.87 additional information binding of ADAMTS13 to CD36 on cell surfaces might be involved in ADAMTS13 regulation and regulation of von Willebrand cleavage Homo sapiens
3.4.24.87 physiological function ADAMTS13 plays a significant role in vascular biology and thrombotic thrombocytopenic purpura Homo sapiens