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Literature summary extracted from

  • Kim, C.E.; Lee, S.J.; Seo, K.W.; Park, H.M.; Yun, J.W.; Bae, J.U.; Bae, S.S.; Kim, C.D.
    Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway (2010), Toxicol. Appl. Pharmacol., 245, 76-82.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 J774A.1 cell
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 Mus musculus
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1.13.11.34 macrophage
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 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
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 Mus musculus leukotriene A4 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
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 Mus musculus
1.13.11.34 5-LO
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 Mus musculus

Expression

EC Number Organism Comment Expression
1.13.11.34 Mus musculus stimulation of J774A.1 cells with 0.01 mM acrolein for 4-24 h leads to increased 5-LO expression through activation of the ERK pathway. Acrolein-induced 5-LO expression is inhibited in a dose-dependent manner by pretreatment with AG1478, but not by pretreatment with AG1295 up

General Information

EC Number General Information Comment Organism
1.13.11.34 metabolism 5-lipoxygenase is involved in the production of matrix metalloproteinase-9 Mus musculus