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Literature summary extracted from

  • Hyun, J.; Kim, H.K.; Kim, J.E.; Lim, M.G.; Jung, J.S.; Park, S.; Cho, H.I.
    Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation (2009), Thromb. Res., 124, 75-79.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.87 diagnostics ADAMTS-13 may serve as a diagnostic and prognostic marker of disseminated intravascular coagulation. Patients with a low activity of ADAMTS-13 have a poor survival rate compared to patients with a high activity of ADAMTS-13 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular
-
 Homo sapiens
-
-
3.4.24.87 intracellular
-
 Homo sapiens 5622
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 endothelial cell
-
 Homo sapiens
-
3.4.24.87 additional information ADAMTS-13 levels in healthy controls and patients with disseminated intravascular coagulation Homo sapiens
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3.4.24.87 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13 i.e. a disintegrin-like and metalloprotease with trombospondin type-1 repeats 13 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.87 additional information ADAMTS-13 activity gradually decreases based on the disseminated intravascular coagulation score and D-dimer levels and is correlated with the antithrombin level, representing the consumption of ADAMTS-13 during the ongoing coagulation process. No correlation between ADAMTS-13 activity and neutrophil CD64 expression Homo sapiens