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Literature summary extracted from

  • Banerjee, H.; Palenchar, J.B.; Lukaszewicz, M.; Bojarska, E.; Stepinski, J.; Jemielity, J.; Guranowski, A.; Ng, S.; Wah, D.A.; Darzynkiewicz, E.; Bellofatto, V.
    Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins (2009), RNA, 15, 1554-1564.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.29 expressed in Escherichia coli BL21(DE3) cells Trypanosoma brucei

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.29 H355N inactive Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.29 Trypanosoma brucei
-
-
-
3.6.1.29 Trypanosoma brucei 427
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.29 Ni-NTA agarose column chromatography Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.29 GpppA + H2O
-
 Trypanosoma brucei GMP + ADP + GDP + AMP
-
 ?
3.6.1.29 GpppA + H2O
-
 Trypanosoma brucei 427 GMP + ADP + GDP + AMP
-
 ?
3.6.1.29 m27,2'OGpppG + H2O
-
 Trypanosoma brucei ppm27,2'OG + guanosine monophosphate
-
 ?
3.6.1.29 m27,2'OGpppG + H2O
-
 Trypanosoma brucei 427 ppm27,2'OG + guanosine monophosphate
-
 ?
3.6.1.29 m2N2,7GpppG + H2O
-
 Trypanosoma brucei pm2N2,7G + guanosine diphosphate
-
 ?
3.6.1.29 m3N2,N2,7GpppA + H2O
-
 Trypanosoma brucei ppm3N2,N2,7G + adenosine monophosphate
-
 ?
3.6.1.29 m3N2,N2,7GpppG + H2O
-
 Trypanosoma brucei ppm3N2,N2,7G + guanosine monophosphate
-
 ?
3.6.1.29 m7GpppA + H2O
-
 Trypanosoma brucei N7-methyl-GMP + ADP + N7-methyl-GDP + AMP
-
 ?
3.6.1.29 m7GpppG + H2O
-
 Trypanosoma brucei pm7G + guanosine diphosphate
-
 ?
3.6.1.29 m7Gpppm3N6,N6,2'OA + H2O
-
 Trypanosoma brucei pm7G + ppm3N6,N6,2'OA
-
 ?
3.6.1.29 m7Gpppm7G + H2O
-
 Trypanosoma brucei N7-methyl-GMP + N7-methyl-GDP
-
 ?
3.6.1.29 m7GpppmN6A + H2O
-
 Trypanosoma brucei pm7G + ppmN6A
-
 ?
3.6.1.29 additional information the enzyme does not hydrolyze Cap 4 m7Gpppm3N6,N6,2'O, Apm2'OApm2'OCpm2N3,2'OU, m7GpppApApCpU, m7GpCH2ppG, and m7Gpppm3N6,N6,2'OApm29OA Trypanosoma brucei ?
-
 ?
3.6.1.29 additional information the enzyme does not hydrolyze Cap 4 m7Gpppm3N6,N6,2'O, Apm2'OApm2'OCpm2N3,2'OU, m7GpppApApCpU, m7GpCH2ppG, and m7Gpppm3N6,N6,2'OApm29OA Trypanosoma brucei 427 ?
-
 ?
3.6.1.29 P1-P3-bis(5'-adenosyl) triphosphate + H2O highest specificity Trypanosoma brucei ADP + AMP
-
 ?
3.6.1.29 P1-P3-bis(5'-adenosyl) triphosphate + H2O highest specificity Trypanosoma brucei 427 ADP + AMP
-
 ?
3.6.1.29 P1-P3-bis(5'-guanosyl) triphosphate + H2O
-
 Trypanosoma brucei GDP + GMP
-
 ?
3.6.1.29 P1-P3-bis(5'-guanosyl) triphosphate + H2O
-
 Trypanosoma brucei 427 GDP + GMP
-
 ?
3.6.1.29 P1-P5-bis(5'-adenosyl) pentaphosphate + H2O
-
 Trypanosoma brucei adenosine monophosphate + adenosine tetraphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.29 FHIT protein/dinucleoside triphosphatase
-
 Trypanosoma brucei
3.6.1.29 HIT-45 protein
-
 Trypanosoma brucei