Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Miller, J.L.; Velmurugan, K.; Cowan, M.J.; Briken, V.
    The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis (2010), PLoS Pathog., 6, e1000864.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 3-azido-ubiquinone-2
-
 Mycobacterium tuberculosis
7.1.1.2 6-amino-4-(4-tert-butylphenethylamino)quinazoline
-
 Mycobacterium tuberculosis
7.1.1.2 6-azido-4-(4-iodophenethylamino)quinazoline the compound specifically binds to the 49000 Da and ND1 subunits with a frequency of about 4:1 Mycobacterium tuberculosis
7.1.1.2 bullatacin
-
 Mycobacterium tuberculosis
7.1.1.2 fenpyroximate
-
 Mycobacterium tuberculosis
7.1.1.2 Piericidin A
-
 Mycobacterium tuberculosis
7.1.1.2 pyridabene
-
 Mycobacterium tuberculosis
7.1.1.2 rotenone
-
 Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Mycobacterium tuberculosis
-
-
-
7.1.1.2 Mycobacterium tuberculosis H37RV (ATCC 25618)
-
-
-

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 NDH-1 the NuoG subunit of the type I NADH dehydrogenase Mycobacterium tuberculosis
7.1.1.2 type I NADH dehydrogenase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 0.0000045
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 6-amino-4-(4-tert-butylphenethylamino)quinazoline

General Information

EC Number General Information Comment Organism
7.1.1.2 physiological function the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mycobacterium tuberculosis-mediated inhibition of host macrophage apoptosis, the NDH-1 complex is important for NOX2 neutralization in host macrophages Mycobacterium tuberculosis