Literature summary extracted from

Larkin, D.; de Laat, B.; Jenkins, P.V.; Bunn, J.; Craig, A.G.; Terraube, V.; Preston, R.J.; Donkor, C.; Grau, G.E.; van Mourik, J.A.; ODonnell, J.S.
Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition (2009), PLoS Pathog., 5, e1000349.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.87	additional information	infection with Plasmodium falciparum inhibits ADAMTS13. ADAMTS13 activity in normal plasma is reduced by approximately 60% after pooled normal plasma is incubated in a 3:1 mix with malarial plasma for 30 min	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.24.87	extracellular	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.24.87	von Willebrand factor + H2O	Homo sapiens	cleavage at the Tyr1605-Met1606 bond within the van Willebrand factor A2 domain	von Willebrand factor fragments	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.87	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.87	plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.87	von Willebrand factor + H2O	-	Homo sapiens	von Willebrand factor fragments	-	?
3.4.24.87	von Willebrand factor + H2O	cleavage at the Tyr1605-Met1606 bond within the van Willebrand factor A2 domain	Homo sapiens	von Willebrand factor fragments	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.87	ADAMTS13	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.4.24.87	37	-	assay at	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.24.87	physiological function	ADAMTS13 regulates normal plasma van Willebrand factor multimer composition and thereby activity, through cleavage at the Tyr1605-Met1606 bond within the van Willebrand factor A2 domain	Homo sapiens

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Release 2023.1 (January 2023)