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Literature summary extracted from

  • Mao, R.; Zhang, J.; Jiang, D.; Cai, D.; Levy, J.M.; Cuconati, A.; Block, T.M.; Guo, J.T.; Guo, H.
    Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells (2011), J. Virol., 85, 1048-1057.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-L-tryptophan
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens P14902
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.13.11.52 Homo sapiens IDO expression is not induced by interferon-alpha additional information
1.13.11.52 Homo sapiens IDO is an interferon-gamma-induced enzyme up

General Information

EC Number General Information Comment Organism
1.13.11.52 physiological function indoleamine 2,3-dioxygenase mediates the antiviral effect of interferon-gamma against hepatitis B virus in human hepatocyte-derived cells, indoleamine 2,3-dioxygenase efficiently reduces the level of intracellular hepatitis B virus DNA without altering the steady-state level of viral RNA Homo sapiens