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Literature summary extracted from

  • Liou, G.F.; Yoshizawa, S.; Courvalin, P.; Galimand, M.
    Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens (2006), J. Mol. Biol., 359, 358-364.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA plasmid pAT780 methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.179 plasmid pAT780
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.179
-
 plasmid pAT780

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes plasmid pAT780 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the ArmA methylation reaction is specific for the 30S ribosomal subunit. Neither 16S rRNA alone nor the 70S ribosome is a substrate for this reaction under experimental conditions, implicating ribosomal proteins in substrate recognition plasmid pAT780 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.179 ArmA
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 plasmid pAT780

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.179 30
-
 assay at plasmid pAT780

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.179 7.5
-
 assay at plasmid pAT780

General Information

EC Number General Information Comment Organism
2.1.1.179 physiological function G1405 methylation produces aminoglycoside resistance by diminishing the affinity of the ribosome for gentamicin plasmid pAT780