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Literature summary extracted from

  • Soubhye, J.; Prevost, M.; Van Antwerpen, P.; Zouaoui Boudjeltia, K.; Rousseau, A.; Furtmueller, P.G.; Obinger, C.; Vanhaeverbeek, M.; Ducobu, J.; Neve, J.; Gelbcke, M.; Dufrasne, F.O.
    Structure-Bbased design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors (2010), J. Med. Chem., 53, 8747-8759.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.7 1-(5-fluoro-1H-indol-3-yl)methanamine
-
 Homo sapiens
1.11.1.7 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
-
 Homo sapiens
1.11.1.7 2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
-
 Homo sapiens
1.11.1.7 3-(5-fluoro-1H-indol-3-yl)-N,N-dimethylpropan-1-amine
-
 Homo sapiens
1.11.1.7 3-(5-fluoro-1H-indol-3-yl)-N-methylpropan-1-amine
-
 Homo sapiens
1.11.1.7 3-(5-fluoro-1H-indol-3-yl)-N-propylpropan-1-amine
-
 Homo sapiens
1.11.1.7 3-(5-fluoro-1H-indol-3-yl)propan-1-amine
-
 Homo sapiens
1.11.1.7 4-(5-fluoro-1H-indol-3-yl)butan-1-amine
-
 Homo sapiens
1.11.1.7 5-(5-fluoro-1H-indol-3-yl)pentan-1-amine
-
 Homo sapiens
1.11.1.7 5-chlorotryptamine
-
 Homo sapiens
1.11.1.7 5-fluoro-3-[(4-methylpiperazin-1-yl)methyl]-1H-indole
-
 Homo sapiens
1.11.1.7 5-fluoro-3-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole
-
 Homo sapiens
1.11.1.7 5-fluoro-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole
-
 Homo sapiens
1.11.1.7 5-fluoro-3-[3-(4-methylpiperazin-1-yl)propyl]-1H-indole
-
 Homo sapiens
1.11.1.7 5-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1H-indol
-
 Homo sapiens
1.11.1.7 5-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1H-indole
-
 Homo sapiens
1.11.1.7 5-fluorotryptamine
-
 Homo sapiens
1.11.1.7 6-(5-fluoro-1H-indol-3-yl)hexan-1-amine
-
 Homo sapiens
1.11.1.7 Flufenamic acid
-
 Homo sapiens
1.11.1.7 N,N-diethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
-
 Homo sapiens
1.11.1.7 N,N-diethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
-
 Homo sapiens
1.11.1.7 N-ethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
-
 Homo sapiens
1.11.1.7 N-ethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
-
 Homo sapiens
1.11.1.7 N-ethyl-N-[(5-fluoro-1H-indol-3-yl)methyl]ethanamine
-
 Homo sapiens
1.11.1.7 N-[2-(5-fluoro-1H-indol-3-yl)ethyl]butan-1-amine
-
 Homo sapiens
1.11.1.7 N-[2-(5-fluoro-1H-indol-3-yl)ethyl]propan-1-amine
-
 Homo sapiens
1.11.1.7 N-[3-(5-fluoro-1H-indol-3-yl)propyl]butan-1-amine
-
 Homo sapiens
1.11.1.7 tryptamine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.7 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.7 taurine + Cl- + H2O2
-
 Homo sapiens taurine chloramine + HOCl + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.7 MPO
-
 Homo sapiens
1.11.1.7 myeloperoxidase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.7 heme
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.11.1.7 0.000008
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-(5-fluoro-1H-indol-3-yl)pentan-1-amine
1.11.1.7 0.000015
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 4-(5-fluoro-1H-indol-3-yl)butan-1-amine
1.11.1.7 0.00004
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole
1.11.1.7 0.00005
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)propan-1-amine
1.11.1.7 0.00009
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine
1.11.1.7 0.00013
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)-N,N-dimethylpropan-1-amine
1.11.1.7 0.00016
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N,N-diethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
1.11.1.7 0.00017
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)-N-propylpropan-1-amine
1.11.1.7 0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluorotryptamine
1.11.1.7 0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-ethyl-N-[(5-fluoro-1H-indol-3-yl)methyl]ethanamine
1.11.1.7 0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
1.11.1.7 0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole
1.11.1.7 0.0002
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 3-(5-fluoro-1H-indol-3-yl)-N-methylpropan-1-amine
1.11.1.7 0.00026
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 6-(5-fluoro-1H-indol-3-yl)hexan-1-amine
1.11.1.7 0.0003
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-ethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
1.11.1.7 0.0003
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-ethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
1.11.1.7 0.00032
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1H-indol
1.11.1.7 0.00035
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N,N-diethyl-3-(5-fluoro-1H-indol-3-yl)propan-1-amine
1.11.1.7 0.00035
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[3-(4-methylpiperazin-1-yl)propyl]-1H-indole
1.11.1.7 0.0008
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-[2-(5-fluoro-1H-indol-3-yl)ethyl]propan-1-amine
1.11.1.7 0.0009
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 1-(5-fluoro-1H-indol-3-yl)methanamine
1.11.1.7 0.001
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens 5-fluoro-3-[(4-methylpiperazin-1-yl)methyl]-1H-indole
1.11.1.7 0.00103
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-[2-(5-fluoro-1H-indol-3-yl)ethyl]butan-1-amine
1.11.1.7 0.0015
-
 in phosphate buffer pH 7.4, at 37°C Homo sapiens N-[3-(5-fluoro-1H-indol-3-yl)propyl]butan-1-amine