Any feedback?
Literature summary extracted from
- Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain (2009), J. Med. Chem., 52, 4613-4622.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.99 | (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide | i.e. (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide or N-arachidonoylethanolamine, competitive | Mus musculus |  |
| 3.5.1.99 | 2-iodobenzylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 2-iodobenzyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 2-iodophenethylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 2-iodophenethyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 2-methoxyphenethylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 2-methoxyphenethyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 3-iodobenzylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 3-iodobenzyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 3-iodophenethylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 3-iodophenethyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 3-methoxyphenethylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 3-methoxyphenethyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 4-iodobenzylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 4-iodobenzyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 4-iodophenethylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 4-iodophenethyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | 4-methoxyphenethylarachidonoylamide | - |
Mus musculus | |
| 3.5.1.99 | 4-methoxyphenethyllinoleoylamide | - |
Mus musculus | |
| 3.5.1.99 | methyl arachidonyl fluorophosphonate | MAFP, a potent irreversible FAAH inhibitor | Mus musculus | |
| 3.5.1.99 | additional information | synthesis of 18 aryl analogues of anandamide. In vitro evaluation of inhibitory potency, binding to CB1 and CB2 cannabinoid receptors, and potential as metabolic trapping tracers of 4-methoxyphenethyllinoleoylamide and 4-methoxyphenethylarachidonoylamide, overview | Mus musculus | |
| 3.5.1.99 | N-(2-hydroxyethyl)linoleoylamide | competitive versus anadamide | Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.99 | anandamide + H2O | Mus musculus | - |
arachidonic acid + ethanolamine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.99 | Mus musculus | - |
male C75BL/6J mice | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.99 | brain | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.99 | anandamide + H2O | - |
Mus musculus | arachidonic acid + ethanolamine | - |
? | |
| 3.5.1.99 | N-(2-hydroxyethyl)linoleoylamide + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.99 | FAAH | - |
Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.99 | 37 | - |
assay at | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.99 | 7.6 | - |
assay at | Mus musculus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.99 | additional information | - |
pIC50, i.e. -log IC50. values of anadamide analogue inhibitors, overview | Mus musculus | additional information |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.5.1.99 | physiological function | importance of FAAH in controlling endogenous anandamide levels in the brain and consequently the importance of FAAH as a regulatory enzyme for key physiological functions. FAAH is one of the main enzymes responsible for terminating the signaling of endocannabinoids in the brain, it has a role in neuropsychiatric disorders | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
