EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | Alda-1 | i.e. N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide, 0.01 mM Alda-1 increases acetaldehyde oxidation by wild type ALDH2 and the Asian variant E487K approximately 1.5 and 6fold, respectively. Alda-1 stimulates established ALDH2 activities by improving NAD+ binding but does not improve the nitroglycerin binding affinity of the Asian variant E487K | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.3 | expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.1.3 | E487K | the East Asian variant results in very low aldehyde dehydrogenase activity and catalyzes nitroglycerin denitration with about 7fold lower maximal rates than the wild type enzyme1 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | Alda-1 | 0.01 mM Alda-1 inhibits the apparent formaldehyde oxidation activity of the wild type enzyme by about 90% | Homo sapiens | |
1.2.1.3 | NAD+ | pronounced inhibition occurs at above 5 mM | Homo sapiens | |
1.2.1.3 | nitroglycerin | exposure of ALDH2 to nitroglycerin results in mechanism-based oxidative inactivation of the enzyme that is partially reversed by dithiothreitol | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.1.3 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.3 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.3 | - |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.3 | acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
? | |
1.2.1.3 | formaldehyde + NAD+ + H2O | - |
Homo sapiens | formate + NADH + H+ | - |
? | |
1.2.1.3 | nitroglycerin + NAD+ + H2O | - |
Homo sapiens | 1,2-glyceryl dinitrate + NO + NADH + H+ | - |
? | |
1.2.1.3 | propionaldehyde + NAD+ + H2O | - |
Homo sapiens | propionate + NADH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.3 | aldehyde dehydrogenase-2 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.3 | NAD+ | - |
Homo sapiens |