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Literature summary extracted from

  • Leopoldini, M.; Malaj, N.; Toscano, M.; Sindona, G.; Russo, N.
    On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme (2010), J. Agric. Food Chem., 58, 10768-10773.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 brutieridin i.e. hesperetin 7-(2''-alpha-rhamnosyl-6''-(3''''-hydroxy-3''''-methylglutaryl)-beta-D-glucoside), a flavonoid conjugate from bergamot fruit extract, structural analogue of statins, computational study, overview Homo sapiens
1.1.1.34 melitidin i.e. naringenin 7-(2''-alpha-rhamnosyl-6''-(3''''-hydroxy-3''''-methylglutaryl)-beta-D-glucoside), a flavonoid conjugate from bergamot fruit extract, structural analogue of statins, computational study, overview Homo sapiens
1.1.1.34 additional information statins are potent enzyme inhibitors that bind to the active site where also the natural substrate binds, used widely in the treatment of hypercholesterolemia Homo sapiens
1.1.1.34 simvastatin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Homo sapiens P04035
-
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA reductase
-
 Homo sapiens
1.1.1.34 HMGR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADP+
-
 Homo sapiens
1.1.1.34 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.34 metabolism HMGR catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols. Mevalonate is a precursor of isoprenoids, a class of compounds involved in several cellular functions such as cholesterol synthesis and growth control Homo sapiens
1.1.1.34 additional information modelling of the active site using crystal stucture of the enzyme with bound inhibitor simvastatin, PDB ID 1HW9, overview Homo sapiens
1.1.1.34 physiological function within cells, the concentration of mevalonate and therefore that of its metabolic products is tightly controlled through the activity of HMGR, an enzyme that catalyzes the four-electron reduction of 3-hydroxy-3-methylglutaryl-CoA to mevalonate Homo sapiens