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Literature summary extracted from

  • An, E.; Sen, S.; Park, S.K.; Gordish-Dressman, H.; Hathout, Y.
    Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome (2010), Invest. Ophthalmol. Vis. Sci., 51, 3379-3386.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.107 ADAM9 + H2O Homo sapiens 54% cleavage ?
-
 ?
3.4.21.107 alpha2-macroglobulin + H2O Homo sapiens 55% cleavage ?
-
 ?
3.4.21.107 chloride intracellular channel protein 1 + H2O Homo sapiens 51% cleavage ?
-
 ?
3.4.21.107 clusterin + H2O Homo sapiens 50% cleavage ?
-
 ?
3.4.21.107 fascin + H2O Homo sapiens 40% cleavage ?
-
 ?
3.4.21.107 fibromodulin + H2O Homo sapiens 90% cleavage ?
-
 ?
3.4.21.107 additional information Homo sapiens HTRA1 does not cleave CFH protein, complement component C3 and complement component C3b ?
-
 ?
3.4.21.107 talin-1 + H2O Homo sapiens 21% cleavage ?
-
 ?
3.4.21.107 Vitronectin + H2O Homo sapiens 54% cleavage ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.107 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.107 retinal pigment epithelium
-
 Homo sapiens
-
3.4.21.107 secretion
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.107 ADAM9 + H2O 54% cleavage Homo sapiens ?
-
 ?
3.4.21.107 alpha2-macroglobulin + H2O 55% cleavage Homo sapiens ?
-
 ?
3.4.21.107 chloride intracellular channel protein 1 + H2O 51% cleavage Homo sapiens ?
-
 ?
3.4.21.107 clusterin + H2O 50% cleavage Homo sapiens ?
-
 ?
3.4.21.107 fascin + H2O 40% cleavage Homo sapiens ?
-
 ?
3.4.21.107 fibromodulin + H2O 90% cleavage Homo sapiens ?
-
 ?
3.4.21.107 additional information HTRA1 does not cleave CFH protein, complement component C3 and complement component C3b Homo sapiens ?
-
 ?
3.4.21.107 talin-1 + H2O 21% cleavage Homo sapiens ?
-
 ?
3.4.21.107 Vitronectin + H2O 54% cleavage Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 HtrA1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.107 Homo sapiens HTRA1 mRNA levels are 3fold higher in primary RPE cells homozygous for the HTRA1 promoter risk allele (rs11200638 -512 G>A), than in RPE cells with the wild type allele. This translates into a 2fold increase in HTRA1 secretion by RPE cells with the risk genotype up

General Information

EC Number General Information Comment Organism
3.4.21.107 malfunction HTRA1 is involved in complement regulation and amyloid deposition in age-related macular degeneration pathogenesis Homo sapiens