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Literature summary extracted from

  • Wang, Y.J.; Jiang, Y.L.; Tang, H.F.; Zhao, C.Z.; Chen, J.Q.
    Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model (2010), Int. Immunopharmacol., 10, 252-258.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 dexamethasone dexmethasone at 0.1 mg/kg inhibits the activity of PDE4 Rattus norvegicus
3.1.4.53 rolipram rolipram at 0.3 mg/kg inhibits the activity of PDE4 Rattus norvegicus
3.1.4.53 Zl-n-91 selective PDE4 inhibitor, Zl-n-91 at 0.03, 0.3 or 3 mg/kg dose dependently inhibits PDE4 activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O Rattus norvegicus
-
 5'-AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O
-
 Rattus norvegicus 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 PDE4
-
 Rattus norvegicus
3.1.4.53 phosphodiesterase 4
-
 Rattus norvegicus