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Literature summary extracted from
- Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats (2010), Hepatology, 51, 277-285.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.23 | bile acid | feedback inhibition preventing the accumulation of cytotoxic hydrophobic bile acids | Rattus norvegicus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.23 | Rattus norvegicus | - |
lactating postpartum female rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.23 | liver | - |
Rattus norvegicus | - |
| 1.14.14.23 | additional information | Cyp7a1 and the bile acid pool size are increased 2-3fold in lactating postpartum rats, the regulatory mechanism functions via altered interaction of nuclear receptors with the Cyp7a1 proximal promoter and altered expression of regulatory signaling pathways in postpartum rats at day 10 | Rattus norvegicus | - |
| 1.14.14.23 | small intestine | - |
Rattus norvegicus | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.23 | cholesterol 7alpha-hydroxylase | - |
Rattus norvegicus |
| 1.14.14.23 | CYP7A1 | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.14.23 | Rattus norvegicus | several negative feedback loops within the liver and small intestine down-regulate Cyp7a1 transcription to prevent accumulation of bile acids to toxic levels. The the JNK/c-Jun pathway is involved in downregulation of Cyp7a1, overview | down |
| 1.14.14.23 | Rattus norvegicus | rodent Cyp7a1 expression increases in response to cholesterol-enriched diets, resulting in increased bile acid synthesis | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.14.23 | metabolism | cholesterol 7alpha-hydroxylase, Cyp7a1, catalyzes the rate-limiting step of the classical pathway of bile acid synthesis and is the major mechanism for cholesterol catabolism and removal from the body. Cyp7a1 regulation, detailed overview | Rattus norvegicus |
| 1.14.14.23 | physiological function | regulation of Cyp7a1 expression is critical for maintenance of cholesterol and bile acid homeostasis | Rattus norvegicus |
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Release 2023.1 (January 2023)
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