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Literature summary extracted from

  • Hail, N.; Chen, P.; Kepa, J.J.; Bushman, L.R.; Shearn, C.
    Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis (2010), Free Radic. Biol. Med., 49, 109-116.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.5.2 expression of GFP-tagged enzyme in SW480 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.2 teriflunomide a redox-silent coenzyme Q antagonist of DHODH Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.2 mitochondrial inner membrane
-
 Homo sapiens 5743
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.2 L-dihydroorotate + FMN Homo sapiens
-
 orotate + FMNH2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.2 COLO-16 cell
-
 Homo sapiens
-
1.3.5.2 HaCaT cell premalignant Homo sapiens
-
1.3.5.2 keratinocyte
-
 Homo sapiens
-
1.3.5.2 additional information no activity in colorectal carcinoma cells Homo sapiens
-
1.3.5.2 prostate epithelium DHODH protein is expressed in premalignant and malignant prostate epithelial cells Homo sapiens
-
1.3.5.2 PWR-1E cell
-
 Homo sapiens
-
1.3.5.2 skin DHODH protein is expressed in premalignant and malignant skin cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.2 L-dihydroorotate + FMN
-
 Homo sapiens orotate + FMNH2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.2 DHODH
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.2 FMN
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.5.2 Homo sapiens suppression of enzyme expression by siRNA of DHODH down

General Information

EC Number General Information Comment Organism
1.3.5.2 physiological function dihydroorotate dehydrogenase is associated with mitochondrial electron transport and required for de novo pyrimidine synthesis, and is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis. Chemical inhibition of DHODH activity or the reduction of DHODH protein suppresses 4HPR-induced ROS production and apoptosis in transformed skin and prostate epithelial cells, overview Homo sapiens