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Literature summary extracted from

  • Herraiz, T.; Gonzalez, D.; Ancin-Azpilicueta, C.; Aran, V.J.; Guillen, H.
    beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO) (2010), Food Chem. Toxicol., 48, 839-845.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 Harmaline identification by HPLC-ESI-mass spectrometry. Potent reversible and strong inhibition of MAO-A, poor inhibition of MAO-B, from seeds Homo sapiens
1.4.3.4 harmalol identification by HPLC-ESI-mass spectrometry Homo sapiens
1.4.3.4 harmine identification by HPLC-ESI-mass spectrometry. Potent reversible and strong inhibition of MAO-A, poor inhibition of MAO-B, from seeds Homo sapiens
1.4.3.4 harmol identification by HPLC-ESI-mass spectrometry Homo sapiens
1.4.3.4 additional information enzyme inhibition by beta-carboline alkaloids from seeds and roots of Peganum harmala, low levels in stems and leaves, and absence in flowers, overview. Seed extracts are potent reversible and competitive inhibitors of human MAO-A with an IC50 of 0.027 mg/L whereas root extracts strongly inhibit MAO-A with an IC50 of 0.159 mg/L. In contrast, they are poor inhibitors of MAO-B. Inhibition of MAO-A by seed extracts is quantitatively attributed to harmaline and harmine whereas inhibition by root extracts came from harmine with no additional interferences Homo sapiens
1.4.3.4 tetrahydroharmine identification by HPLC-ESI-mass spectrometry Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + O2
-
 Homo sapiens 4-hydroxyquinoline + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 7.4
-
 assay at Homo sapiens