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Literature summary extracted from

  • Di Pucchio, T.; Danese, S.; De Cristofaro, R.; Rutella, S.
    Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds (2010), Expert Opin. Ther. Pat., 20, 229-250.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-D-tryptophan competitive inhibitor Homo sapiens
1.13.11.52 1-methyl-L-tryptophan competitive inhibitor Homo sapiens
1.13.11.52 4-amino-1,2,3-oxadiazole-3-carboximidamide
-
 Homo sapiens
1.13.11.52 annulin B
-
 Homo sapiens
1.13.11.52 beta-carboline
-
 Homo sapiens
1.13.11.52 brassinin
-
 Homo sapiens
1.13.11.52 epigallocatechin gallate
-
 Homo sapiens
1.13.11.52 exiguamine A
-
 Homo sapiens
1.13.11.52 exiguamine B
-
 Homo sapiens
1.13.11.52 menadione
-
 Homo sapiens
1.13.11.52 methyl-thiohydantoin-L-tryptophan competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 dendritic cell
-
 Homo sapiens
-
1.13.11.52 fibroblast
-
 Homo sapiens
-
1.13.11.52 macrophage
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO1
-
 Homo sapiens
1.13.11.52 indoleamine 2,3-dioxygenase 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.019
-
 1-methyl-L-tryptophan pH and temperature not specified in the publication Homo sapiens
1.13.11.52 0.1
-
 1-methyl-D-tryptophan pH and temperature not specified in the publication Homo sapiens

Expression

EC Number Organism Comment Expression
1.13.11.52 Homo sapiens IDO expression is negatively regulated by interleukin-4, nitric oxide and transforming growth factor-beta down
1.13.11.52 Homo sapiens IDO expression is positively regulated by interferon-gamma, CD40 ligand, COX-2, lipopolysaccharide, tumor necrosis factor-alpha, and hepatocyte growth factor up

General Information

EC Number General Information Comment Organism
1.13.11.52 physiological function indoleamine 2,3-dioxygenase activity is implicated in the promotion of tolerance to tumors and in autoimmune and inflammatory conditions, itplays a role in arthritis, ischemia-reperfusion injury, haemostatic system, sepsis, atherosclerosis, diabetes, and gut, allergy, and airway inflammation Homo sapiens