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Literature summary extracted from

  • Liu, X.; Cheng, J.C.; Turner, L.S.; Elojeimy, S.; Beckham, T.H.; Bielawska, A.; Keane, T.E.; Hannun, Y.A.; Norris, J.S.
    Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy (2009), Expert Opin. Ther. Targets, 13, 1449-1458.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.5.1.23 drug development development of small molecule drugs, that inhibit AC enzyme activity, is a promising approach for improving standard cancer therapy and patient's clinical outcomes Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.23 acid ceramidase maps to 8p22, the region of chromosome 8 most frequently deleted in prostate cancer. Regulation of gene expression by acid ceramidase in prostate cancer cells, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.23 additional information a germ line single nucleotide polymorphism creates a splice site resulting in alternatively-spliced KLF6 isoforms, termed KLF6 SV1, SV2 and SV3. The splice variants show that SV1 has a counteracting effect on the wild-type KLF6 tumor suppressor activity, thus permitting tumor progression Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.23 lysosome predominantly Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 prostate cancer cell acid ceramidase upregulation in prostate cancer Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.23 dimer the 53 kDa acid ceramidase pre-polypeptide undergoes autocatalytic processing into two subunits of 13 and 40 kDa, respectively Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.5.1.23 acid ceramidase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.5.1.23 Homo sapiens radiation-induced acid ceramidase upregulation confers resistance to taxane up

General Information

EC Number General Information Comment Organism
3.5.1.23 metabolism ceramide metabolism, sphingolipid signaling, and aberrant ceramide signaling and cancer development, overview. Pathways of sphingolipid metabolism, overview Homo sapiens
3.5.1.23 additional information human acid ceramidase deficiency is associated with Farber disease. It plays a role in androgen depletion therapy and in resistance to chemotherapy and to radiation therapy, overview Homo sapiens
3.5.1.23 physiological function the enzyme is involved in ceramide metabolism and is a critical regulator of cancer cell growth and/or survival, acid ceramidase upregulation in prostate cancer plays a role in tumor development. A dysfunctional ceramide pathway is responsible for tumor progression and resistance to chemotherapy and radiation Homo sapiens