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Literature summary extracted from
- Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery (2010), Eur. J. Med. Chem., 45, 5899-5909.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.3.98.1 | enzyme in complex with orotate, crystal structure analysis, overview | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.98.1 | 1,5-dihydrofuro[3,4-d]pyrimidine-2,4,7-trione | - |
Homo sapiens |  |
| 1.3.98.1 | 2,3-dihydrotriazolo[4,5-d]pyrimidine-5,7-dione | - |
Homo sapiens | |
| 1.3.98.1 | 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
| 1.3.98.1 | 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid | - |
Homo sapiens | |
| 1.3.98.1 | 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
| 1.3.98.1 | 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
| 1.3.98.1 | 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
| 1.3.98.1 | 5-[(dimethylamino)methyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | - |
Homo sapiens | |
| 1.3.98.1 | 7,9-dihydro-3H-purine-2,6,8-trione | - |
Homo sapiens | |
| 1.3.98.1 | butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate | - |
Homo sapiens | |
| 1.3.98.1 | additional information | inhibitor virtual screening, overview | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.3.98.1 | membrane | anchored | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.98.1 | L-dihydroorotate + fumarate | Homo sapiens | - |
orotate + succinate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.98.1 | Trypanosoma cruzi | Q4D3W2 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.98.1 | L-dihydroorotate + fumarate | - |
Homo sapiens | orotate + succinate | - |
? | |
| 1.3.98.1 | additional information | three-dimensional active site structure, profile of interactions for molecular recognition, interaction of DHODH with orotate via residues Asn212, Asn284, Ser215, Phe149, Lys100, Gly148, Asn217, Asn145, and Thr285, overview | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.3.98.1 | More | structure comparisons of enzymes from Trypanosoma cruzi, Leishmania major, and Homo sapiens, overview | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.98.1 | DHODH | - |
Homo sapiens |
| 1.3.98.1 | More | class 2 DHODH family enzyme | Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.3.98.1 | 25 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.3.98.1 | 8 | - |
assay at | Homo sapiens |
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