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Literature summary extracted from

  • Ojha, P.K.; Roy, K.
    Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials (2010), Eur. J. Med. Chem., 45, 4645-4656.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.2 4-[(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]-2-(trifluoromethyl)benzonitrile
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-(2,3,4-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-(2,4,5-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-(3-methylphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-(4-methylphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-(4-nitrophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 5-methyl-N-[4-methyl-3-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 additional information development and evaluation of triazolopyrimidine-based DHODH inhibitors, overview. Detailed quantitative structure-activity relationship study and molecular docking studies, the 2-methyltriazolopyrimidine ring interacts with some polar and some nonpolar amino acids whereas the substituted phenyl ring binds with a hydrophobic pocket of the enzyme formed by some nonpolar amino acid residues, overview Plasmodium falciparum
1.3.5.2 N-(2,3-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(2-fluoro-4-methylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(3,4-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(3,4-dimethylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(3,5-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(3-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(3-fluoro-4-methylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(4-benzylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(4-bromophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(4-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(4-fluoro-3-methylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(4-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(4-methoxyphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-(biphenyl-4-yl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-[4-(difluoromethoxy)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-[4-bromo-3-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum
1.3.5.2 N-[4-chloro-3-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
 Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.2 mitochondrion
-
 Plasmodium falciparum 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.2 L-dihydroorotate + FMN Plasmodium falciparum
-
 orotate + FMNH2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.2 Plasmodium falciparum Q08210
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.2 L-dihydroorotate + FMN
-
 Plasmodium falciparum orotate + FMNH2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.5.2 DHODH
-
 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.2 FMN dependent on Plasmodium falciparum

General Information

EC Number General Information Comment Organism
1.3.5.2 physiological function Plasmodium DHODH is an essential mitochondrial enzyme that catalyzes the flavin mononucleotide-dependent formation of orotic acid, a key step in de novo pyrimidine biosynthesis Plasmodium falciparum