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Literature summary extracted from

  • Fujiwara, K.; Kikuchi, M.; Horiguchi, K.; Kusumoto, K.; Kouki, T.; Kawanishi, K.; Yashiro, T.
    Estrogen receptor alpha regulates retinaldehyde dehydrogenase 1 expression in rat anterior pituitary cells (2009), Endocr. J., 56, 963-973.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.36 55000
-
SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Rattus norvegicus P51647
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 anterior pituitary
-
Rattus norvegicus
-
1.2.1.36 pituitary gland
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O
-
Rattus norvegicus retinoate + NADH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 RalDH1
-
Rattus norvegicus
1.2.1.36 retinaldehyde dehydrogenase 1
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Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.2.1.36 Rattus norvegicus levels of RALDH1 gene expression and protein production markedly decrease after 1-week treatment with 17beta-estradiol in male rats. Treatment of isolated anterior pituitary cells with 17beta-estradiol (0.00001-10 nM) decreases expression of RALDH1 mRNA in a dose-dependent manner (about 55% RALDH1 mRNA level remaining 6 h after treatment with 10 nM 17beta-estradiol). 17beta-Estradiol-induced suppression of RALDH1 expression is completely blocked by the estrogen receptor antagonist ICI 182, 780. The ERalpha-selective agonist propylpyrazole triol (10 nM) mimicks the effect of 17beta-estradiol on RALDH1 expression, but the ERbeta-selective agonist diarylpropionitrile (10 nM) does not down