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Literature summary extracted from

  • Mancuso, C.; Barone, E.
    The heme oxygenase/biliverdin reductase pathway in drug research and development (2009), Curr. Drug Metab., 10, 579-594.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.24 bilirubin inhibits the enzyme in a feedback regulation system, biliverdin inhibits the heme oxygenase activity, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.24 cytosol
-
 Homo sapiens 5829
-
1.3.1.24 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 bilirubin + NAD+ Homo sapiens
-
 biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NAD+ Rattus norvegicus
-
 biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Rattus norvegicus
-
 biliverdin + NADPH + H+
-
 r
1.3.1.24 additional information Homo sapiens the enzyme shows dual cofactor- and pH-dependency in activity ?
-
 ?
1.3.1.24 additional information Rattus norvegicus the enzyme shows dual cofactor- and pH-dependency in activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens
-
-
-
1.3.1.24 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 brain BVR expression patterns, overview Homo sapiens
-
1.3.1.24 brain co-expression with heme oxygenases HO-1 and HO-2, BVR expression patterns, overview Rattus norvegicus
-
1.3.1.24 brain cortex
-
 Rattus norvegicus
-
1.3.1.24 cerebellum
-
 Rattus norvegicus
-
1.3.1.24 hippocampus
-
 Rattus norvegicus
-
1.3.1.24 additional information the BVR activity progressively increases after birth and reaches adult levels by postpartum day 28 Rattus norvegicus
-
1.3.1.24 neuron
-
 Rattus norvegicus
-
1.3.1.24 substantia nigra
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NAD+
-
 Homo sapiens biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NAD+
-
 Rattus norvegicus biliverdin + NADH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Rattus norvegicus biliverdin + NADPH + H+
-
 r
1.3.1.24 additional information the enzyme shows dual cofactor- and pH-dependency in activity Homo sapiens ?
-
 ?
1.3.1.24 additional information the enzyme shows dual cofactor- and pH-dependency in activity Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 BV reductase
-
 Homo sapiens
1.3.1.24 BV reductase
-
 Rattus norvegicus
1.3.1.24 BVR
-
 Homo sapiens
1.3.1.24 BVR
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.24 additional information
-
 the enzyme shows dual cofactor- and pH-dependency in activity Homo sapiens
1.3.1.24 additional information
-
 the enzyme shows dual cofactor- and pH-dependency in activity Rattus norvegicus
1.3.1.24 6.8
-
 with NADH Homo sapiens
1.3.1.24 8.7
-
 with NADPH Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 additional information the enzyme shows dual cofactor- and pH-dependency in activity Homo sapiens
1.3.1.24 additional information the enzyme shows dual cofactor- and pH-dependency in activity Rattus norvegicus
1.3.1.24 NAD+
-
 Homo sapiens
1.3.1.24 NAD+
-
 Rattus norvegicus
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADH
-
 Rattus norvegicus
1.3.1.24 NADP+
-
 Homo sapiens
1.3.1.24 NADP+
-
 Rattus norvegicus
1.3.1.24 NADPH
-
 Homo sapiens
1.3.1.24 NADPH
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.3.1.24 Homo sapiens BVR expression is unaffected by heat shock additional information
1.3.1.24 Homo sapiens BVR is induced by lipopolysaccharides and bromobenzene at a post-transcriptional level up

General Information

EC Number General Information Comment Organism
1.3.1.24 metabolism the heme oxygenase/biliverdin reductase axis is the main metabolic pathway for heme degradation. Activation during stress results in increased heme degradation and acceleration of biliverdin transformation to bilirubin Homo sapiens
1.3.1.24 metabolism the heme oxygenase/biliverdin reductase axis is the main metabolic pathway for heme degradation. Activation suirng stress results in increased heme degradation and acceleration of biliverdin transformation to bilirubin Rattus norvegicus
1.3.1.24 additional information pharmacodynamics of the heme oxygenase/biliverdin reductase system, overview Homo sapiens
1.3.1.24 physiological function BV reductase regulates cell growth and apoptosis, its knockdown increases apoptosis. The BVR also phosphorylates the insulin receptor substrate 1, IRS-1, on serine residues preventing its phosphorylation by insulin receptor, which represent a physiological mechanism for increasing glucose uptake. And BVR is a nuclear transporter of ERK1/2 with metabolic regulatory role Homo sapiens
1.3.1.24 physiological function BV reductase regulates cell growth and apoptosis, its knockdown increases apoptosis. The BVR also phosphorylates the insulin receptor substrate 1, IRS-1, on serine residues preventing its phosphorylation by insulin receptor, which represent a physiological mechanism for increasing glucose uptake. And BVR is a nuclear transporter of ERK1/2 with metabolic regulatory role Rattus norvegicus