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Literature summary extracted from

  • Konno, R.; Hamase, K.; Maruyama, R.; Zaitsu, K.
    Mutant mice and rats lacking D-amino acid oxidase (2010), Chem. Biodivers., 7, 1450-1458.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.3 G181R naturally occuring missense mutation, inactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2 Mus musculus
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 Rattus norvegicus
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Mus musculus
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2 Rattus norvegicus
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Mus musculus
-
-
-
1.4.3.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 astrocyte
-
 Rattus norvegicus
-
1.4.3.3 brain
-
 Mus musculus
-
1.4.3.3 brain
-
 Rattus norvegicus
-
1.4.3.3 kidney
-
 Mus musculus
-
1.4.3.3 additional information D-serine occurs in the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdale, D-serine tissue distribution, overview Rattus norvegicus
-
1.4.3.3 additional information no activity in liver. D-serine occurs in the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdale, D-serine tissue distribution, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2
-
 Mus musculus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Rattus norvegicus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Mus musculus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Mus musculus
1.4.3.3 DAO
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Mus musculus
1.4.3.3 FAD
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.4.3.3 metabolism D-serine is synthesized from L-serine by serine racemase and degraded by D-amino acid oxidase in neurons, overview Mus musculus
1.4.3.3 metabolism D-serine is synthesized from L-serine by serine racemase and degraded by D-amino acid oxidase in neurons, overview Rattus norvegicus
1.4.3.3 additional information phenotypes of mutant mice resulting from enhanced N-methyl-D-aspartate receptor function, accumulation of D-amino acids in the organs and body fluids of mutant mice, overview. Mutant mice lacking DAO do not show great abnormalities, but responses to the nociceptive stimuli are different between the mutant and wild-type mice. The function of NMDA receptors is enhanced in the mutant mice, with long-term potentiation in the CA1 area of hippocampus being augmented. Mutant mice display an anxiety-like behavior and have aminoaciduria Mus musculus
1.4.3.3 physiological function DAO is associated with schizophrenia. DAO modulates neurotransmission by metabolizing the D-serine, that binds to the coagonist-binding site of N-methyl-D-aspartate subtype of glutamate receptors and enhances the neurotransmission Mus musculus
1.4.3.3 physiological function DAO is associated with schizophrenia. DAO modulates neurotransmission by metabolizing the D-serine, that binds to the coagonist-binding site of N-methyl-D-aspartate subtype of glutamate receptors and enhances the neurotransmission. DAO might be involved in D-serine-induced nephrotoxicity only in rats Rattus norvegicus