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Literature summary extracted from

  • Stagos, D.; Chen, Y.; Cantore, M.; Jester, J.V.; Vasiliou, V.
    Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization (2010), Brain Res. Bull., 81, 211-218.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytoplasm
-
 Mus musculus 5737
-
1.2.1.3 cytoplasm isoform ALDH3A1 Oryctolagus cuniculus 5737
-
1.2.1.3 nucleus
-
 Mus musculus 5634
-
1.2.1.3 nucleus isoform ALDH3A1 Oryctolagus cuniculus 5634
-
1.2.1.5 nucleus isoform ALDH3A1 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O Oryctolagus cuniculus
-
 4-hydroxynon-2-enoate + NADH + H+
-
 ?
1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O Mus musculus
-
 4-hydroxynon-2-enoic acid + NADH
-
 ?
1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O Mus musculus poor substrate of isoform ALDH3A1 4-hydroxynon-2-enoic acid + NADH
-
 ?
1.2.1.3 malondialdehyde + NAD+ + H2O Mus musculus
-
 ?
-
 ?
1.2.1.3 malondialdehyde + NAD+ + H2O Oryctolagus cuniculus poor substrate of isoform ALDH3A1 ?
-
 ?
1.2.1.5 4-hydroxy-2-nonenal + NAD(P)+ + H2O Mus musculus
-
 ? + NAD(P)H + H+
-
 ?
1.2.1.5 malondialdehyde + NAD(P)+ + H2O Mus musculus
-
 ? + NAD(P)H + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Mus musculus P47738 isoform ALDH2
-
1.2.1.3 Mus musculus Q3UNF5 isoform ALDH3A1
-
1.2.1.3 Mus musculus Q9CZS1 isoform ALDH1B1
-
1.2.1.3 Mus musculus Q9DBF1 isoform ALDH7A1
-
1.2.1.3 Oryctolagus cuniculus
-
-
-
1.2.1.5 Mus musculus Q9JHW9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 cornea
-
 Mus musculus
-
1.2.1.3 keratocyte
-
 Oryctolagus cuniculus
-
1.2.1.3 lens
-
 Mus musculus
-
1.2.1.3 TRK-43 cell
-
 Oryctolagus cuniculus
-
1.2.1.5 corneal epithelium isoform ALDH3A1 Mus musculus
-
1.2.1.5 keratocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O
-
 Oryctolagus cuniculus 4-hydroxynon-2-enoate + NADH + H+
-
 ?
1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O
-
 Mus musculus 4-hydroxynon-2-enoic acid + NADH
-
 ?
1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O poor substrate of isoform ALDH3A1 Mus musculus 4-hydroxynon-2-enoic acid + NADH
-
 ?
1.2.1.3 malondialdehyde + NAD+ + H2O
-
 Mus musculus ?
-
 ?
1.2.1.3 malondialdehyde + NAD+ + H2O poor substrate of isoform ALDH3A1 Oryctolagus cuniculus ?
-
 ?
1.2.1.5 4-hydroxy-2-nonenal + NAD(P)+ + H2O
-
 Mus musculus ? + NAD(P)H + H+
-
 ?
1.2.1.5 malondialdehyde + NAD(P)+ + H2O
-
 Mus musculus ? + NAD(P)H + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.3 homodimer isoform ALDH3A1 Oryctolagus cuniculus
1.2.1.3 homodimer isoform ALDH3A1 Mus musculus
1.2.1.3 homotetramer isoform ALDH1B1 Mus musculus
1.2.1.5 homodimer isoform ALDH3A1 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 Aldh1b1 isoform, formerly known as ALDHx or ALDH5 Mus musculus
1.2.1.3 ALDH2 isoform Mus musculus
1.2.1.3 ALDH3A1 isoform Oryctolagus cuniculus
1.2.1.3 ALDH3A1 isoform Mus musculus
1.2.1.3 Aldh7a1 isoform Mus musculus
1.2.1.5 ALDH3A1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Oryctolagus cuniculus
1.2.1.3 NAD+
-
 Mus musculus
1.2.1.5 NAD+
-
 Mus musculus
1.2.1.5 NADP+
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.2.1.3 Oryctolagus cuniculus isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14 up
1.2.1.3 Mus musculus isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14 up

General Information

EC Number General Information Comment Organism
1.2.1.3 malfunction decreased ALDH3A1 activity is associated with pathologic corneas (cataract development) Oryctolagus cuniculus
1.2.1.3 malfunction decreased ALDH3A1 activity is associated with pathologic corneas (cataract development) Mus musculus
1.2.1.3 metabolism isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism Oryctolagus cuniculus
1.2.1.3 metabolism isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism Mus musculus
1.2.1.3 physiological function isoform ALDH1A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues Mus musculus
1.2.1.3 physiological function isoform ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues. The nuclear presence of isoform ALDH3A1 may be involved in cell cycle regulation Mus musculus
1.2.1.3 physiological function isoforms ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues. The nuclear presence of isoform ALDH3A1 may be involved in cell cycle regulation Oryctolagus cuniculus
1.2.1.5 physiological function isoforms ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues, detoxifies reactive aldehydes and acts as antioxidant Mus musculus