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Literature summary extracted from

  • Feng, Y.; Huang, S.L.; Dou, W.; Zhang, S.; Chen, J.H.; Shen, Y.; Shen, J.H.; Leng, Y.
    Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice (2010), Br. J. Pharmacol., 161, 113-126.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.146 expressed in HEK-293 cell Mus musculus
1.1.1.146 expressed in HEK-293 cell Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 3-methylchrysazin
-
 Homo sapiens
1.1.1.146 3-methylchrysazin
-
 Mus musculus
1.1.1.146 Aloe-emodin
-
 Homo sapiens
1.1.1.146 Aloe-emodin
-
 Mus musculus
1.1.1.146 emodin
-
 Homo sapiens
1.1.1.146 emodin
-
 Mus musculus
1.1.1.146 Rhein
-
 Mus musculus
1.1.1.146 rheochrysidin
-
 Homo sapiens
1.1.1.146 rheochrysidin
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens P28845
-
-
1.1.1.146 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.146
-
 Mus musculus
1.1.1.146
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Mus musculus cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.146 0.000081
-
 pH 7.4, 37°C Mus musculus rheochrysidin
1.1.1.146 0.000086
-
 pH 7.4, 37°C Mus musculus emodin
1.1.1.146 0.000098
-
 pH 7.4, 37°C Mus musculus Aloe-emodin
1.1.1.146 0.000186
-
 pH 7.4, 37°C Homo sapiens emodin
1.1.1.146 0.0004
-
 pH 7.4, 37°C Mus musculus 3-methylchrysazin
1.1.1.146 0.000542
-
 pH 7.4, 37°C Homo sapiens rheochrysidin
1.1.1.146 0.000879
-
 pH 7.4, 37°C Homo sapiens Aloe-emodin
1.1.1.146 0.00284
-
 pH 7.4, 37°C Mus musculus Rhein
1.1.1.146 0.00354
-
 pH 7.4, 37°C Homo sapiens 3-methylchrysazin