Literature summary extracted from

Liu, S.H.; Shen, C.C.; Yi, Y.C.; Tsai, J.J.; Wang, C.C.; Chueh, J.T.; Lin, K.L.; Lee, T.C.; Pan, H.C.; Sheu, M.L.
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals (2010), Br. J. Pharmacol., 160, 1963-1972.

Application

EC Number	Application	Comment	Organism
1.13.11.12	medicine	induction of 15-LOX-1-mediated down-regulation of a PPAR-gamma and COX-2 pathway by honokiol is a therapeutic strategy for gastric cancer	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.12	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.12	AGS cell	-	Homo sapiens	-
1.13.11.12	MKN-45 cell	-	Homo sapiens	-
1.13.11.12	NCI-N87 cell	-	Homo sapiens	-
1.13.11.12	SC-M1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.12	linoleate + O2	-	Homo sapiens	(9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate	primary product	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.13.11.12	15-lipoxygenase-1	-	Homo sapiens
1.13.11.12	15-LOX-1	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
1.13.11.12	Homo sapiens	0.04 mM honokiol markedly activates cellular 15-LOX-1 expression	up

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Release 2023.1 (January 2023)