Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kwak, G.H.; Choi, S.H.; Kim, H.Y.
    Dimethyl sulfoxide elevates hydrogen peroxide-mediated cell death in Saccharomyces cerevisiae by inhibiting the antioxidant function of methionine sulfoxide reductase A (2010), BMB Rep., 43, 622-628.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.11 dimethyl sulfoxide DMSO competitively inhibits the methionine-sulfoxide reduction ability of MsrA (12% residual activity at 0.1% (v/v) DMSO) and inhibits the antioxidant function of MsrA in yeast cells, resulting in higher sensitivity to oxidative stress Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + 2 dithiothreitol Saccharomyces cerevisiae
-
 L-methionine + dithiothreitol disulfide + H2O
-
 ?
1.8.4.11 L-methionine (S)-sulfoxide + 2 dithiothreitol Saccharomyces cerevisiae BY4741
-
 L-methionine + dithiothreitol disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Saccharomyces cerevisiae
-
-
-
1.8.4.11 Saccharomyces cerevisiae BY4741
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.11 Talon-metal affinity column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 dabsyl-L-methionine-(S)-S-sulfoxide + dithiothreitol
-
 Saccharomyces cerevisiae dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
 ?
1.8.4.11 dabsyl-L-methionine-(S)-S-sulfoxide + dithiothreitol
-
 Saccharomyces cerevisiae BY4741 dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
 ?
1.8.4.11 L-methionine (S)-sulfoxide + 2 dithiothreitol
-
 Saccharomyces cerevisiae L-methionine + dithiothreitol disulfide + H2O
-
 ?
1.8.4.11 L-methionine (S)-sulfoxide + 2 dithiothreitol
-
 Saccharomyces cerevisiae BY4741 L-methionine + dithiothreitol disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Saccharomyces cerevisiae
1.8.4.11 MsrA
-
 Saccharomyces cerevisiae