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Literature summary extracted from

  • Turner, N.A.; Nolasco, L.; Ruggeri, Z.M.; Moake, J.L.
    Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage (2009), Blood, 114, 5102-5111.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.87 additional information specific blockade of von Willebrand factor string cleavage by antibody to ADAMTS-13, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular ADAMTS-13 is released directly from the Golgi to the cell exterior without an organelle storage site, e.g. a cytoplasmic granule Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.87 Ca2+ required Homo sapiens
3.4.24.87 Zn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens ADAMTS-13 cleavage of von Willebrand factor strings secreted from stimulated and unstimulated HUVECs occurs at the position 1605-6 of the von Willebrand factor A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 endothelial cell obtained from collagenase-digested human umbilical veins, ADAMTS-13 is released directly from the Golgi to the cell exterior without an organelle storage site, e.g. a cytoplasmic granule Homo sapiens
-
3.4.24.87 plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.87 additional information
-
 more ADAMTS-13-mediated cleavage of the relatively few von Willebrand factor strings secreted at a slow rate from unstimulated HUVECs, and less ADAMTS-13 cleavage of the many von Willebrand factor strings secreted rapidly in response to cell stimulation Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O ADAMTS-13 cleavage of von Willebrand factor strings secreted from stimulated and unstimulated HUVECs occurs at the position 1605-6 of the von Willebrand factor A2 domain Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
3.4.24.87 von Willebrand factor + H2O ADAMTS-13 cleavage of HUVEC-secreted von Willebrand factor strings at Y1605-6M sites of the von Willebrand factor A2 domain Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS-13
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.87 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.87 7.4
-
 assay at Homo sapiens