Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Laje, P.; Shang, D.; Cao, W.; Niiya, M.; Endo, M.; Radu, A.; DeRogatis, N.; Scheiflinger, F.; Zoltick, P.W.; Flake, A.W.; Zheng, X.L.
    Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy (2009), Blood, 113, 2172-2180.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 gene Adamts13, DNA and amino acid sequence determination, construction of self-inactivated lentiviral vector, and expression of functional His-tagged ADAMTS13 cDNA in COS-7 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.87 additional information plasma ADAMTS13 proteolytic activity on average can be restored in Adamts13-/- mice to approximately 25% of wild-type level by autologous transplantation of hematopoietic progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding a full-length murine Adamts13 and an enhanced GFP reporter gene Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular
-
 Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.87 Ba2+ activates Mus musculus
3.4.24.87 Ca2+ activates Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Mus musculus
-
 gene Adamts13
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 plasma
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.87 additional information
-
 determination of ADAMTS13 antigen and proteolytic activity in murine plasma, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 additional information assay on the fluorogenic substrate FRETS-vWF73 Mus musculus ?
-
 ?
3.4.24.87 von Willebrand factor + H2O
-
 Mus musculus ?
-
 ?
3.4.24.87 von Willebrand factor + H2O substrate of human origin Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.87 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.87 7.5 8 assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.4.24.87 additional information genetic or acquired deficiency of plasma ADAMTS13 activity leads to a potentially fatal syndrome, thrombotic thrombocytopenic purpura, TTP Mus musculus