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Literature summary extracted from

  • Akashi, T.; Sawada, Y.; Aoki, T.; Ayabe, S.
    New scheme of the biosynthesis of formononetin involving 2,7,4'-trihydroxyisoflavanone but not daidzein as the methyl acceptor (2000), Biosci. Biotechnol. Biochem., 64, 2276-2279.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.87 expressed in Saccharomyces cerevisiae microsomes Glycyrrhiza echinata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.212 S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone Glycyrrhiza echinata the enzyme is involved in formononetin biosynthesis S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
2.1.1.212 S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone Glycyrrhiza echinata AK-1 the enzyme is involved in formononetin biosynthesis S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.87 Glycyrrhiza echinata
-
-
-
2.1.1.212 Glycyrrhiza echinata Q84KK6
-
-
2.1.1.212 Glycyrrhiza echinata AK-1 Q84KK6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.87 (2S)-liquiritigenin + [reduced NADPH-hemoprotein reductase] + O2
-
 Glycyrrhiza echinata 2,7,4'-trihydroxyisoflavanone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.87 additional information the enzyme also produces a spirodienone intermediate from (2S)-liquiritigenin which further reacts to 2,7-dihydroxy-4'-methoxyisoflavanone and formononetin Glycyrrhiza echinata ?
-
 ?
2.1.1.212 S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
-
 Glycyrrhiza echinata S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
2.1.1.212 S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone the enzyme is involved in formononetin biosynthesis Glycyrrhiza echinata S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
2.1.1.212 S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
-
 Glycyrrhiza echinata AK-1 S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
2.1.1.212 S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone the enzyme is involved in formononetin biosynthesis Glycyrrhiza echinata AK-1 S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.87 2-hydroxyisoflavanone synthase
-
 Glycyrrhiza echinata
1.14.14.87 CYP93C2
-
 Glycyrrhiza echinata
1.14.14.87 IFS
-
 Glycyrrhiza echinata