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Literature summary extracted from
- Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues (2010), Bioorg. Med. Chem., 18, 1018-1028.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.4 | 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens |  |
| 1.4.3.4 | 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
| 1.4.3.4 | 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
| 1.4.3.4 | 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
| 1.4.3.4 | 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
| 1.4.3.4 | 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
| 1.4.3.4 | 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Homo sapiens | |
| 1.4.3.4 | 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | - |
Papio anubis | |
| 1.4.3.4 | additional information | inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues, quantitative structure-activity relationship studies, overview | Homo sapiens | |
| 1.4.3.4 | additional information | inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues, quantitative structure-activity relationship studies, overview | Papio anubis |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | 0.0161 | - |
kynuramine | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.0227 | - |
kynuramine | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.0683 | - |
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.4.3.4 | mitochondrion | - |
Homo sapiens | 5739 | - |
| 1.4.3.4 | mitochondrion | - |
Papio anubis | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | Homo sapiens | - |
- |
- |
| 1.4.3.4 | Papio anubis | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | liver | - |
Papio anubis | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.4 | 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2 | i.e. MMTP, is oxidized to the corresponding dihydropyridinium metabolite, MMDP+ | Homo sapiens | ? | - |
? | |
| 1.4.3.4 | 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine + H2O + O2 | i.e. MMTP, is oxidized to the corresponding dihydropyridinium metabolite, MMDP+ | Papio anubis | ? | - |
? | |
| 1.4.3.4 | kynuramine + O2 | - |
Homo sapiens | 4-hydroxyquinoline + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | kynuramine + O2 | - |
Papio anubis | 4-hydroxyquinoline + NH3 + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | MAO-A | - |
Homo sapiens |
| 1.4.3.4 | MAO-A | - |
Papio anubis |
| 1.4.3.4 | MAO-B | - |
Homo sapiens |
| 1.4.3.4 | MAO-B | - |
Papio anubis |
| 1.4.3.4 | monoamine oxidase A | - |
Homo sapiens |
| 1.4.3.4 | monoamine oxidase A | - |
Papio anubis |
| 1.4.3.4 | monoamine oxidase B | - |
Homo sapiens |
| 1.4.3.4 | monoamine oxidase B | - |
Papio anubis |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
| 1.4.3.4 | additional information | - |
additional information | inhibition kinetics | Papio anubis | |
| 1.4.3.4 | 0.000023 | - |
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.000036 | - |
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.000051 | - |
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.000065 | - |
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
| 1.4.3.4 | 0.000065 | - |
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
| 1.4.3.4 | 0.000069 | - |
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
| 1.4.3.4 | 0.00014 | - |
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.00018 | - |
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.00018 | - |
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.00023 | - |
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.00031 | - |
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
| 1.4.3.4 | 0.00033 | - |
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.00034 | - |
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.00037 | - |
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.0004 | - |
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
| 1.4.3.4 | 0.00043 | - |
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.00059 | - |
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | |
| 1.4.3.4 | 0.00092 | - |
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
| 1.4.3.4 | 0.0011 | - |
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.0013 | - |
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | |
| 1.4.3.4 | 0.00144 | - |
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | 0.000068 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000107 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000112 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000113 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00012 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000152 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.0004 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000534 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000542 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000546 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00067 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.000698 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00094 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00101 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00107 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00124 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00159 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00177 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-A | Homo sapiens | 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00249 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Papio anubis | 8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00315 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione | |
| 1.4.3.4 | 0.00372 | - |
pH not specified in the publication, temperature not specified in the publication, MAO-B | Homo sapiens | 1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione | |
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