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Literature summary extracted from

  • Hauske, P.; Meltzer, M.; Ottmann, C.; Krojer, T.; Clausen, T.; Ehrmann, M.; Kaiser, M.
    Selectivity profiling of DegP substrates and inhibitors (2009), Bioorg. Med. Chem., 17, 2920-2924.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.107 additional information not inhibited by SGRVVPGYGHA-chloromethylketone and IWNTLNSGRVVPGTGHA-chloromethylketone Escherichia coli
3.4.21.107 PMMGKASPV-chloromethylketone 49% residual activity at 0.5 mM Escherichia coli
3.4.21.107 PVFNTLPMMGKASPV-chloromethylketone 63% residual activity at 0.5 mM Escherichia coli
3.4.21.107 SPMFKGV-chloromethylketone 3% residual activity at 0.5 mM Escherichia coli
3.4.21.107 VFNTLPMMGKASPV-chloromethylketone 57% residual activity at 0.5 mM Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.107 Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.107 0.001
-
 using PMMGKASPV-4-nitroanilide as substrate, in 50 mM NaH2PO4, pH 8.0, temperature not specified in the publication Escherichia coli
3.4.21.107 0.018
-
 using PVFNTLPMMGKASPV-4-nitroanilide as substrate, in 50 mM NaH2PO4, pH 8.0, temperature not specified in the publication Escherichia coli
3.4.21.107 0.018
-
 using SPMFKGV-4-nitroanilide as substrate, in 50 mM NaH2PO4, pH 8.0, temperature not specified in the publication Escherichia coli
3.4.21.107 0.032
-
 using VFNTLPMMGKASPV-4-nitroanilide as substrate, in 50 mM NaH2PO4, pH 8.0, temperature not specified in the publication Escherichia coli
3.4.21.107 0.473
-
 using DPMFKLV-4-nitroanilide as substrate, in 50 mM NaH2PO4, pH 8.0, temperature not specified in the publication Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.107 DPMFKLV-4-nitroanilide + H2O
-
 Escherichia coli DPMFKLV + 4-nitroaniline
-
 ?
3.4.21.107 additional information almost no activity towards SDAEFRHDSGYEV-4-nitroanilide, SDAEFRHDSGYEV-4-nitroanilide, SGRVVPGYGHA-4-nitroanilide, SPLPEGV-4-nitroanilide , GLATGNVSTAELQDATPA-4-nitroanilide, KGKNSGSGATPV-4-nitroanilide, KGASVPGAGLV-4-nitroanilide, SPAKGGEEPLPEGV-4-nitroanilide, and benzoyl-L-Arg-4-nitroanilide Escherichia coli ?
-
 ?
3.4.21.107 PMMGKASPV-4-nitroanilide + H2O
-
 Escherichia coli PMMGKASPV + 4-nitroaniline
-
 ?
3.4.21.107 PVFNTLPMMGKASPV-4-nitroanilide + H2O
-
 Escherichia coli PVFNTLPMMGKASPV + 4-nitroaniline
-
 ?
3.4.21.107 SPMFKGV-4-nitroanilide + H2O
-
 Escherichia coli SPMFKGV + 4-nitroaniline
-
 ?
3.4.21.107 VFNTLPMMGKASPV-4-nitroanilide + H2O
-
 Escherichia coli VFNTLPMMGKASPV + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 DegP
-
 Escherichia coli