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Literature summary extracted from

  • Yu, G.; Praveen Rao, P.N.; Chowdhury, M.A.; Abdellatif, K.R.; Dong, Y.; Das, D.; Velazquez, C.A.; Suresh, M.R.; Knaus, E.E.
    Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase (2010), Bioorg. Med. Chem. Lett., 20, 2168-2173.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 (1-difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)acetic acid
-
 Solanum tuberosum
1.13.11.34 (1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)acetic acid
-
 Solanum tuberosum
1.13.11.34 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)propanoic acid
-
 Solanum tuberosum
1.13.11.34 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)propanoic acid
-
 Solanum tuberosum
1.13.11.34 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)acetic acid
-
 Solanum tuberosum
1.13.11.34 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)propanoic acid
-
 Solanum tuberosum
1.13.11.34 caffeic acid
-
 Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Solanum tuberosum
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Solanum tuberosum
1.13.11.34 5-LOX
-
 Solanum tuberosum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.00025
-
 pH and temperature not specified in the publication Solanum tuberosum 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)propanoic acid
1.13.11.34 0.00044
-
 pH and temperature not specified in the publication Solanum tuberosum (1-difluoromethyl-2-oxo-1,2-dihydropyridin-4-yl)acetic acid
1.13.11.34 0.00046
-
 pH and temperature not specified in the publication Solanum tuberosum 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)acetic acid
1.13.11.34 0.00077
-
 pH and temperature not specified in the publication Solanum tuberosum (1-difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)acetic acid
1.13.11.34 0.003
-
 pH and temperature not specified in the publication Solanum tuberosum 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-5-yl)propanoic acid
1.13.11.34 0.0037
-
 pH and temperature not specified in the publication Solanum tuberosum 2-(1-difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)propanoic acid
1.13.11.34 0.004
-
 pH and temperature not specified in the publication Solanum tuberosum caffeic acid