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Literature summary extracted from

  • Zaldivar-Machorro, V.J.; Lopez-Ortiz, M.; Demare, P.; Regla, I.; Munoz-Clares, R.A.
    The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial grow (2011), Biochimie, 93, 286-295.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.8 expressed in Escherichia coli Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.8 additional information diethyldithiocarbamic acid does not inactivate the enzyme in vitro and in situ Pseudomonas aeruginosa
1.2.1.8 S-methyl-N,N-diethyldithiocarbamoyl sulfone most potent irreversible inhibition in vitro at 0.05 mM, but no inhibition in situ Pseudomonas aeruginosa
1.2.1.8 S-methyl-N,N-diethyldithiocarbamoyl sulfoxide irreversible inhibition Pseudomonas aeruginosa
1.2.1.8 S-methyl-N,N-diethylthiocarbamoyl sulfone irreversible inhibition Pseudomonas aeruginosa
1.2.1.8 S-methyl-N,N-diethylthiocarbamoyl sulfoxide
-
 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Pseudomonas aeruginosa Q9HTJ1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.8
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD(P)+ + H2O
-
 Pseudomonas aeruginosa betaine + NAD(P)H + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.8 BADH
-
 Pseudomonas aeruginosa
1.2.1.8 betaine aldehyde dehydrogenase
-
 Pseudomonas aeruginosa
1.2.1.8 betaine aldehyde: NAD(P)+ oxidoreductase
-
 Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.8 NAD(P)+
-
 Pseudomonas aeruginosa