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Literature summary extracted from

  • Ochiai, H.; Takeda, K.; Soeda, S.; Tahara, Y.; Takenaka, H.; Abe, K.; Hayashi, Y.; Noguchi, S.; Inoue, M.; Schwarz, S.; Schwarz, W.; Kawamura, M.
    Epigallocatechin-3-gallate is an inhibitor of Na+, K+-ATPase by favoring the E1 conformation (2009), Biochem. Pharmacol., 78, 1069-1074.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 epicatechin
-
 Sus scrofa
7.2.2.13 epicatechin-3-gallate solubilization of the Na+,K+-ATPase with a nonionic detergent reduces sensitivity to epigallocatechin-3-gallate Sus scrofa
7.2.2.13 epigallocatechin
-
 Sus scrofa
7.2.2.13 epigallocatechin-3-gallate noncompetitive with respect to ATP, reduces the affinity for vanadate, shifts the equilibrium of E1P and E2P toward E1P, and reduces the rate of the E1P to E2P transition Sus scrofa
7.2.2.13 vanadate epigallocatechin-3-gallate reduces the affinity for vanadate, shifts the equilibrium of E1P and E2P toward E1P, and reduces the rate of the E1P to E2P transition Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.13 microsome
-
 Sus scrofa
-
-
7.2.2.13 plasma membrane
-
 Sus scrofa 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.13 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out Sus scrofa
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.2.2.13 phosphoprotein reversible phosphorylation of theenzyme during reaction Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 kidney outer medulla Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Sus scrofa ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na+, K+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.13 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.13 7 7.4 assay at Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.13 0.0008
-
 pH 7.0, 37°C Sus scrofa epicatechin-3-gallate
7.2.2.13 0.001
-
 pH 7.0, 37°C Sus scrofa epigallocatechin-3-gallate
7.2.2.13 0.2
-
 pH 7.0, 37°C Sus scrofa epicatechin