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Literature summary extracted from

  • Capeillere-Blandin, C.; Martin, C.; Gaggero, N.; Pasta, P.; Carrea, G.; Colonna, S.
    Sulphoxidation reaction catalysed by myeloperoxidase from human leucocytes (1998), Biochem. J., 335, 27-33.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.11.2.2 chloride in the presence of 100 mM NaCl the catalytic efficiency of MPO increases 3-4fold whatever the sulfide considered, the rate of 4-tolyl methyl sulphide oxidation enhancement is about 8fold at 120 mM NaCl Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.2.2 H2O2 at pH 5.0, H2O2 at high concentrations inhibits the enzyme. The rate of sulfoxide formation increases as the H2O2 concentration increases up to 0.2 mM, while a further increase in concentration results in a decrease in the rate of sulfoxide formation (40% inhibition at 1 mM H2O2) Homo sapiens
1.11.2.2 Sulfide at high sulfide concentrations, enzymic inhibition is observed above 0.25 mM (20% inhibition at 0.3 mM sulfide) Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.2.2 0.012
-
 1-methoxy-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.016
-
 1-acetyl-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.018
-
 thioanisole in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.02
-
 thioanisole in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.026
-
 phenyl propan-2-yl sulfide in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.027
-
 1-chloro-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.03
-
 1-methoxy-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.032
-
 1-methyl-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.039
-
 1-acetyl-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.04
-
 1-methyl-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.041
-
 phenyl propan-2-yl sulfide in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.05
-
 benzyl methyl sulfide in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.057
-
 4-(methylsulfanyl)aniline in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.066
-
 1-nitro-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.067
-
 1-chloro-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.07
-
 H2O2 in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.072
-
 benzothiophene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.076
-
 1-nitro-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.081
-
 benzothiophene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.083
-
 benzyl methyl sulfide in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 0.104
-
 4-(methylsulfanyl)aniline in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.11.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.2.2 leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.2.2 1-acetyl-4-(methylsulfanyl)benzene + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 1-chloro-4-(methylsulfanyl)benzene + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 1-methoxy-4-(methylsulfanyl)benzene + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 1-methyl-4-(methylsulfanyl)benzene + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 1-nitro-4-(methylsulfanyl)benzene + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 4-(methylsulfanyl)aniline + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 4-tolyl methyl sulfide + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 benzothiophene + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 benzyl methyl sulfide + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?
1.11.2.2 phenyl propan-2-yl sulfide + H2O2 + H+
-
 Homo sapiens ?
-
 ?
1.11.2.2 thioanisole + H2O2 + H+
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.2.2 MPO
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.11.2.2 0.43
-
 1-methoxy-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 1
-
 benzyl methyl sulfide in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 1
-
 benzothiophene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 1.6
-
 benzothiophene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 1.8
-
 1-nitro-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 3
-
 1-methyl-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 4
-
 thioanisole in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 4.2
-
 1-acetyl-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 5
-
 1-chloro-4-(methylsulfanyl)benzene in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 5.5
-
 1-nitro-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 6
-
 1-methoxy-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 7.3
-
 phenyl propan-2-yl sulfide in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 8
-
 benzyl methyl sulfide in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 10
-
 4-(methylsulfanyl)aniline in the absence of NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 12
-
 thioanisole in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 14
-
 phenyl propan-2-yl sulfide in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 20
-
 1-methyl-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 35
-
 1-chloro-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 40
-
 4-(methylsulfanyl)aniline in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens
1.11.2.2 56
-
 1-acetyl-4-(methylsulfanyl)benzene in the presence of 100 mM NaCl, in 50 mM acetate buffer, pH 5.0, at 20°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.2.2 heme
-
 Homo sapiens