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Literature summary extracted from

  • Murugan, A.K.; Bojdani, E.; Xing, M.
    Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer (2010), Biochem. Biophys. Res. Commun., 393, 555-559.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.42 gene idh1, expression of Myc-tagged wild-type and Myc-tagged mutant enzymes in HEK-293T cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.42 G123R site-directed mutagenesis, mutation is located in the catalytic domain, the mutant shows reduced activity compared to the wild-type enzyme Homo sapiens
1.1.1.42 R132H site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Homo sapiens
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Homo sapiens O75874 IDH1
-
1.1.1.42 Homo sapiens P48735 IDH2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 B-CPAP cell
-
 Homo sapiens
-
1.1.1.42 C-643 cell
-
 Homo sapiens
-
1.1.1.42 FB-1 cell
-
 Homo sapiens
-
1.1.1.42 FTC-133 cell
-
 Homo sapiens
-
1.1.1.42 HTh-7 cell
-
 Homo sapiens
-
1.1.1.42 HTh-74 cell
-
 Homo sapiens
-
1.1.1.42 KAT-18 cell
-
 Homo sapiens
-
1.1.1.42 OCUT-1 cell
-
 Homo sapiens
-
1.1.1.42 OCUT-2 cell
-
 Homo sapiens
-
1.1.1.42 SW-1736 cell
-
 Homo sapiens
-
1.1.1.42 thyroid cancer cell
-
 Homo sapiens
-
1.1.1.42 thyroid cancer cell line K1 cell Homo sapiens
-
1.1.1.42 thyroid cancer cell line K5 cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Homo sapiens 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 IDH1
-
 Homo sapiens
1.1.1.42 IDH2
-
 Homo sapiens
1.1.1.42 isocitrate dehydrogenase 1
-
 Homo sapiens
1.1.1.42 isocitrate dehydrogenase 2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.42 27
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.42 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
 Homo sapiens