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Literature summary extracted from
- Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts (2010), Biochem. Biophys. Res. Commun., 393, 404-409.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.46 | amyloid precursor protein + H2O | Cricetulus griseus | - |
fragments of amyloid precursor protein | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.46 | Cricetulus griseus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.23.46 | CHO cell | - |
Cricetulus griseus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.46 | amyloid precursor protein + H2O | - |
Cricetulus griseus | fragments of amyloid precursor protein | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.46 | BACE1 | - |
Cricetulus griseus |
| 3.4.23.46 | beta-secretase | - |
Cricetulus griseus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.23.46 | physiological function | BACE1 is a key protein in the pathogenesis of Alzheimer's disease | Cricetulus griseus |
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Release 2023.1 (January 2023)
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