Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Moriki, T.; Maruyama, I.N.; Igari, A.; Ikeda, Y.; Murata, M.
    Identification of ADAMTS13 peptide sequences binding to von Willebrand factor (2010), Biochem. Biophys. Res. Commun., 391, 783-788.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 construction of ADAMTS13 epitope library Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.87 additional information construction and screening of an epitope peptide library, e.g. of epitope-A, i.e. a C-terminus of spacer domain from Arg670 to Gln684, and epitope-B, i.e. Pro618 to Glu641 in the middle of spacer domain. Synthetic epitope-B peptide inhibits the cleavage of VWF by ADAMTS13, while the synthetic epitope-A peptide does inhibit not as efficiently as epitope-B. Elimination of four amino acids from either sides of epitope-B terminus markedly reduces the inhibitory effect Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 additional information structure-function analysis, overview Homo sapiens ?
-
 ?
3.4.24.87 von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.87 von Willebrand factor + H2O identification of ADAMTS13 peptide sequences binding to von Willebrand factor, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
 Homo sapiens