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Literature summary extracted from

  • Drawz, S.M.; Bethel, C.R.; Doppalapudi, V.R.; Sheri, A.; Pagadala, S.R.; Hujer, A.M.; Skalweit, M.J.; Anderson, V.E.; Chen, S.G.; Buynak, J.D.; Bonomo, R.A.
    Penicillin sulfone inhibitors of class D beta-lactamases (2010), Antimicrob. Agents Chemother., 54, 1414-1424.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanic acid
-
 Acinetobacter sp.
3.5.2.6 clavulanic acid
-
 plasmid RGN238
3.5.2.6 clavulanic acid
-
 Pseudomonas aeruginosa
3.5.2.6 JDB/ASR-II-292
-
 Acinetobacter sp.
3.5.2.6 JDB/ASR-II-292
-
 plasmid RGN238
3.5.2.6 JDB/ASR-II-292
-
 Pseudomonas aeruginosa
3.5.2.6 JDB/LN-1-255
-
 Acinetobacter sp.
3.5.2.6 JDB/LN-1-255
-
 plasmid RGN238
3.5.2.6 JDB/LN-1-255
-
 Pseudomonas aeruginosa
3.5.2.6 tazobactam
-
 Acinetobacter sp.
3.5.2.6 tazobactam
-
 plasmid RGN238
3.5.2.6 tazobactam
-
 Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.009
-
 nitrocefin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.009
-
 nitrocefin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 0.031
-
 Oxacillin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.031
-
 Oxacillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 0.064
-
 ampicillin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.064
-
 ampicillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 0.08
-
 cephaloridine pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.08
-
 cephaloridine pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Acinetobacter sp.
-
-
-
3.5.2.6 plasmid RGN238
-
-
-
3.5.2.6 Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Pseudomonas aeruginosa
3.5.2.6
-
 Acinetobacter sp.
3.5.2.6
-
 plasmid RGN238

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ampicillin + H2O
-
 Acinetobacter sp. (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ampicillin + H2O
-
 plasmid RGN238 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Acinetobacter sp. (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O
-
 plasmid RGN238 (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Acinetobacter sp. (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 plasmid RGN238 (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Acinetobacter sp. (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 plasmid RGN238 (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 oxa-1 beta-lactamase
-
 Acinetobacter sp.
3.5.2.6 oxa-1 beta-lactamase
-
 plasmid RGN238
3.5.2.6 OXA-10 beta-lactamase
-
 Pseudomonas aeruginosa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 16
-
 cephaloridine pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 16
-
 cephaloridine pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 96
-
 nitrocefin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 96
-
 nitrocefin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 357
-
 ampicillin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 357
-
 ampicillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 577
-
 Oxacillin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 577
-
 Oxacillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.2.6 0.0007
-
 JDB/LN-1-255 pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.0007
-
 JDB/LN-1-255 pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 0.0014
-
 JDB/ASR-II-292 pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.0014
-
 JDB/ASR-II-292 pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 0.0014
-
 JDB/LN-1-255 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.004
-
 JDB/ASR-II-292 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.008
-
 JDB/LN-1-255 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.017
-
 JDB/ASR-II-292 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.019
-
 clavulanic acid pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.03
-
 tazobactam pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.104
-
 clavulanic acid pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.17
-
 tazobactam pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
3.5.2.6 0.195
-
 clavulanic acid pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.195
-
 clavulanic acid pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 0.585
-
 tazobactam pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 0.585
-
 tazobactam pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.5.2.6 200
-
 cephaloridine pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 200
-
 cephaloridine pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 5578
-
 ampicillin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 5578
-
 ampicillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 10450
-
 nitrocefin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 10450
-
 nitrocefin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
3.5.2.6 18610
-
 Oxacillin pH and temperature not specified in the publication Acinetobacter sp.
3.5.2.6 18610
-
 Oxacillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238