Literature summary extracted from

de Mast, Q.; Groot, E.; Asih, P.B.; Syafruddin, D.; Oosting, M.; Sebastian, S.; Ferwerda, B.; Netea, M.G.; de Groot, P.G.; van der Ven, A.J.; Fijnheer, R.
ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria (2009), Am. J. Trop. Med. Hyg., 80, 492-498.

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.24.87	P475S	the common naturally occuring polymorphsim is not involved in ADAMTS13 inhibition in malaria patients	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.87	additional information	malaria patients possess high ADAMTS13 autoantibodies levels as well as endogenous ADAMTS13 inhibitors compared to healthy controls	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.24.87	extracellular	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.24.87	von Willebrand factor + H2O	Homo sapiens	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.87	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.87	endothelial cell	-	Homo sapiens	-
3.4.24.87	plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.87	von Willebrand factor + H2O	-	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.87	ADAMTS13	-	Homo sapiens
3.4.24.87	von Willebrand factor cleaving protease	-	Homo sapiens
3.4.24.87	VWF cleaving protease	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.24.87	additional information	ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor caused by Plasmodium falciparum and Plasmodium vivax malaria, overview	Homo sapiens

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Release 2023.1 (January 2023)