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Literature summary extracted from

  • Eng, H.; Niosi, M.; McDonald, T.S.; Wolford, A.; Chen, Y.; Simila, S.T.; Bauman, J.N.; Warmus, J.; Kalgutkar, A.S.
    Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor (2010), Xenobiotica, 40, 369-380.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.1 analysis the enzyme with substrate (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone and inhibitor bis(p-nitrophenyl) phosphate are useful in a system to measure in plasma-free fraction for a plasma-labile compound Mus musculus
3.1.1.1 analysis the enzyme with substrate (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone and inhibitor bis(p-nitrophenyl) phosphate are useful in a system to measure in plasma-free fraction for a plasma-labile compound Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 bis(p-nitrophenyl) phosphate a specific inhibitor of carboxylesterases Canis lupus familiaris
3.1.1.1 bis(p-nitrophenyl) phosphate a specific inhibitor of carboxylesterases Homo sapiens
3.1.1.1 bis(p-nitrophenyl) phosphate a specific inhibitor of carboxylesterases Mus musculus
3.1.1.1 bis(p-nitrophenyl) phosphate a specific inhibitor of carboxylesterases Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 extracellular
-
 Mus musculus
-
-
3.1.1.1 extracellular
-
 Homo sapiens
-
-
3.1.1.1 extracellular
-
 Rattus norvegicus
-
-
3.1.1.1 extracellular
-
 Canis lupus familiaris
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.1 (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O Mus musculus
-
 (2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
 ?
3.1.1.1 (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O Rattus norvegicus
-
 (2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Canis lupus familiaris
-
-
-
3.1.1.1 Homo sapiens
-
-
-
3.1.1.1 Mus musculus
-
-
-
3.1.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 blood plasma
-
 Mus musculus
-
3.1.1.1 blood plasma
-
 Homo sapiens
-
3.1.1.1 blood plasma
-
 Rattus norvegicus
-
3.1.1.1 blood plasma
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
-
 Mus musculus (2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
 ?
3.1.1.1 (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O
-
 Rattus norvegicus (2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
 ?
3.1.1.1 (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O cleavage of the amide bond, inhibited by bis(p-nitrophenyl) phosphate Mus musculus (2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
 ?
3.1.1.1 (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone + H2O cleavage of the amide bond, inhibited by bis(p-nitrophenyl) phosphate Rattus norvegicus (2S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline + (isoquinolin-5-yloxy)acetic acid
-
 ?
3.1.1.1 additional information no activity with (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone in plasma Homo sapiens ?
-
 ?
3.1.1.1 additional information no activity with (S)-1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone in plasma Canis lupus familiaris ?
-
 ?