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Literature summary extracted from

  • Zarini, S.; Gijon, M.A.; Ransome, A.E.; Murphy, R.C.; Sala, A.
    Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation (2009), Proc. Natl. Acad. Sci. USA, 106, 8296-8301.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.6 additional information bone marrow cells from LTA4H-/- mice injected into 5LO-/- mice, defective for 5-lipoxygenase, restores the ability to synthesize LTB4, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Mus musculus
-
 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 bone marrow cell
-
 Mus musculus
-
3.3.2.6 peritoneal fluid from lavage Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Mus musculus leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 LTA4 hydrolase
-
 Mus musculus
3.3.2.6 LTA4H
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.3.2.6 metabolism the enzyme is involved in the leukotriene metabolism. In the leukotriene biosynthesis, cells expressing 5-lipoxygenase form LTA4 and transfer it to cells expressing LTA4 hydrolase or LTC4 synthase to produce LTB4 or LTC4 Mus musculus
3.3.2.6 physiological function the enzyme is involved in the leukotriene metabolism, leukotrienes are lipid mediators of inflammation formed by enzymatic oxidation of arachidonic acid Mus musculus