Any feedback?
Literature summary extracted from
- Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism (2009), Neuroscience, 163, 646-661.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.3.2.9 | expression pattern of mEH | Mus musculus |
| 3.3.2.10 | expression pattern of sEH | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.10 | 1-adamantyl-3-cyclohexylurea | a sEH-selective inhibitor | Mus musculus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.9 | 0.00025 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.9 | 0.0005 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.9 | 0.001 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.9 | 0.001 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.0006 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.002 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.002 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.006 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.3.2.9 | microsome | - |
Mus musculus | - |
- |
| 3.3.2.10 | soluble | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | Mus musculus | - |
C57BL/6 mice | - |
| 3.3.2.9 | Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
| 3.3.2.10 | Mus musculus | P34914 | C57BL/6 mice | - |
| 3.3.2.10 | Mus musculus C57BL/6 | P34914 | C57BL/6 mice | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.3.2.9 | amygdala | specific nuclei | Mus musculus | - |
| 3.3.2.9 | astrocyte | - |
Mus musculus | - |
| 3.3.2.9 | brain | mEH distribution, immunohistochemical analysis, overview. mEH immunoreactivity is present in specific neuronal populations of the hippocampus, striatum, amygdala, and cerebellum, as well as in a fraction of astrocytes | Mus musculus | - |
| 3.3.2.9 | cerebellum | - |
Mus musculus | - |
| 3.3.2.9 | choroid plexus | - |
Mus musculus | - |
| 3.3.2.9 | corpus striatum | - |
Mus musculus | - |
| 3.3.2.9 | hindbrain | specific nuclei | Mus musculus | - |
| 3.3.2.9 | hippocampus | - |
Mus musculus | - |
| 3.3.2.9 | midbrain | specific nuclei | Mus musculus | - |
| 3.3.2.9 | neuron | - |
Mus musculus | - |
| 3.3.2.9 | vascular cell | endothelial and smooth muscle cells | Mus musculus | - |
| 3.3.2.10 | amygdala | - |
Mus musculus | - |
| 3.3.2.10 | astrocyte | - |
Mus musculus | - |
| 3.3.2.10 | brain | sEH distribution, immunohistochemical analysis, overview. sEH immunoreactivity is almost exclusively located in astrocytes throughout the brain, except in the central amygdala, where neurons are also positive for sEH | Mus musculus | - |
| 3.3.2.10 | hippocampus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.9 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.9 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
| 3.3.2.10 | (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.3.2.9 | mEH | - |
Mus musculus |
| 3.3.2.10 | SEH | - |
Mus musculus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.3.2.9 | metabolism | epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids. Microsomal epoxide hydrolase is involved in the cerebral epoxyeicosatrienoic acid metabolism | Mus musculus |
| 3.3.2.10 | metabolism | epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids. Soluble epoxide hydrolase mediates the bulk of the cerebral epoxyeicosatrienoic acid metabolism, overview | Mus musculus |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.9 | 0.01 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.9 | 0.01 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.9 | 0.02 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.9 | 5 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.005 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.005 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.05 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
| 3.3.2.10 | 0.5 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
